[HTML][HTML] Drosophila blastoderm patterning
The Drosophila blastoderm embryo is a classic model for the study of the genetics of pattern
formation. In recent years, quantitative empirical approaches have been employed …
formation. In recent years, quantitative empirical approaches have been employed …
Mathematics and biology: a Kantian view on the history of pattern formation theory
S Roth - Development genes and evolution, 2011 - Springer
Driesch's statement, made around 1900, that the physics and chemistry of his day were
unable to explain self-regulation during embryogenesis was correct and could be extended …
unable to explain self-regulation during embryogenesis was correct and could be extended …
The Drosophila pioneer factor Zelda modulates the nuclear microenvironment of a dorsal target enhancer to potentiate transcriptional output
Connecting the developmental patterning of tissues to the mechanistic control of RNA
polymerase II remains a long-term goal of developmental biology. Many key elements have …
polymerase II remains a long-term goal of developmental biology. Many key elements have …
Combining protein and mRNA quantification to decipher transcriptional regulation
We combine immunofluorescence and single-molecule fluorescence in situ hybridization
(smFISH), followed by automated image analysis, to quantify the concentration of nuclear …
(smFISH), followed by automated image analysis, to quantify the concentration of nuclear …
Dissecting the sharp response of a canonical developmental enhancer reveals multiple sources of cooperativity
Developmental enhancers integrate graded concentrations of transcription factors (TFs) to
create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) …
create sharp gene expression boundaries. Here we examine the hunchback P2 (HbP2) …
Precision of Readout at the hunchback Gene: Analyzing Short Transcription Time Traces in Living Fly Embryos
J Desponds, H Tran, T Ferraro, T Lucas… - PLoS computational …, 2016 - journals.plos.org
The simultaneous expression of the hunchback gene in the numerous nuclei of the
developing fly embryo gives us a unique opportunity to study how transcription is regulated …
developing fly embryo gives us a unique opportunity to study how transcription is regulated …
Scaling of the Bicoid morphogen gradient by a volume-dependent production rate
D Cheung, C Miles, M Kreitman, J Ma - Development, 2011 - journals.biologists.com
An important feature of development is the formation of patterns that are proportional to the
overall size of the embryo. But how such proportionality, or scaling, is achieved …
overall size of the embryo. But how such proportionality, or scaling, is achieved …
Mutual repression enhances the steepness and precision of gene expression boundaries
TR Sokolowski, T Erdmann, PR Ten Wolde - 2012 - journals.plos.org
Embryonic development is driven by spatial patterns of gene expression that determine the
fate of each cell in the embryo. While gene expression is often highly erratic, embryonic …
fate of each cell in the embryo. While gene expression is often highly erratic, embryonic …
Adaptation of the length scale and amplitude of the Bicoid gradient profile to achieve robust patterning in abnormally large Drosophila melanogaster embryos
D Cheung, C Miles, M Kreitman, J Ma - Development, 2014 - journals.biologists.com
The formation of patterns that are proportional to the size of the embryo is an intriguing but
poorly understood feature of development. Molecular mechanisms controlling such …
poorly understood feature of development. Molecular mechanisms controlling such …
Transcriptional activators and activation mechanisms
J Ma - Protein & cell, 2011 - academic.oup.com
Transcriptional activators are required to turn on the expression of genes in a eukaryotic cell.
Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to …
Activators bound to the enhancer can facilitate either the recruitment of RNA polymerase II to …