Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Autophagy defects are a risk factor for inflammatory bowel diseases (IBDs) through unknown
mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult …
mechanisms. Whole-body conditional deletion of autophagy-related gene (Atg) Atg7 in adult …
[HTML][HTML] Differential regulation of β-catenin-mediated transcription via N-and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
C Borrelli, T Valenta, K Handler, K Vélez… - Nature …, 2021 - nature.com
The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for …
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for …
[HTML][HTML] INAUGURAL ARTICLE by a Recently Elected Academy Member: Autophagy in PDGFRα+ mesenchymal cells is essential for intestinal stem cell survival
Y Yang, M Gomez, T Marsh, L Poillet-Perez… - Proceedings of the …, 2022 - ncbi.nlm.nih.gov
Leads to Ileum Damage and Death. To address Atg5 function in adult mice, we generated
the inducible Ubc–CreERT2/+; Atg5 flox/flox GEMM and treated these adult mice with five …
the inducible Ubc–CreERT2/+; Atg5 flox/flox GEMM and treated these adult mice with five …
[PDF][PDF] Differential regulation of-catenin-mediated transcription via N-and C-terminal co-factors governs identity of murine intestinal epithelial stem cells
C Borrelli, T Valenta, K Handler, K Vélez, A Gurtner… - 2021 - scholar.archive.org
The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/-catenin signaling is required for …
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/-catenin signaling is required for …
Discrete regulation of β-catenin-mediated transcription governs identity of intestinal epithelial stem cells
C Borrelli, T Valenta, K Handler, K Vélez, G Moro… - bioRxiv, 2020 - biorxiv.org
The homeostasis of the gut epithelium relies upon continuous renewal and proliferation of
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for …
crypt-resident intestinal epithelial stem cells (IESCs). Wnt/β-catenin signaling is required for …
Accumulation of Somatic Mutations in Normal Human Colonic Epithelium
C Olpe - 2020 - repository.cam.ac.uk
I investigated stem cell dynamics in normal human colon by detecting somatic variants
affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral …
affecting X-linked and autosomal genes using immunohistochemistry. Applying neutral …