Hydrogel-based ocular drug delivery systems: Emerging fabrication strategies, applications, and bench-to-bedside manufacturing considerations

RC Cooper, H Yang - Journal of controlled release, 2019 - Elsevier
The physiological barriers of the eye pose challenges to the delivery of the array of
therapeutics for ocular diseases. Hydrogels have been widely explored for medical …

Hydrogels as emerging materials for cornea wound healing

S Khosravimelal, M Mobaraki, S Eftekhari, M Ahearne… - Small, 2021 - Wiley Online Library
Hydrogel biomaterials have many favorable characteristics including tuneable mechanical
behavior, cytocompatibility, optical properties suitable for regeneration and restoration of the …

Recent advancements in polymeric nanofibers for ophthalmic drug delivery and ophthalmic tissue engineering

D Sakpal, S Gharat, M Momin - Biomaterials Advances, 2022 - Elsevier
Nanofibers due to their unique properties such as high surface-to-volume ratio, porous
structure, mechanical strength, flexibility and their resemblance to the extracellular matrix …

Propolis-based nanofiber patches to repair corneal microbial keratitis

S Ulag, E Ilhan, R Demirhan, A Sahin, BK Yilmaz… - Molecules, 2021 - mdpi.com
In this research, polyvinyl-alcohol (PVA)/gelatin (GEL)/propolis (Ps) biocompatible nanofiber
patches were fabricated via electrospinning technique. The controlled release of Propolis …

Chemical structure-related drug-like criteria of global approved drugs

F Mao, W Ni, X Xu, H Wang, J Wang, M Ji, J Li - Molecules, 2016 - mdpi.com
The chemical structure of a drug determines its physicochemical properties, further
determines its ADME/Tox properties, and ultimately affects its pharmacological activity …

Genipin-crosslinked polyvinyl alcohol/silk fibroin/nano-hydroxyapatite hydrogel for fabrication of artificial cornea scaffolds—a novel approach to corneal tissue …

H Zhou, Z Wang, H Cao, H Hu, Z Luo… - Journal of …, 2019 - Taylor & Francis
Abstract Design of artificial corneal scaffolds substitute is crucial for replacement of impaired
cornea. In this paper, porous polyvinyl alcohol/silk fibroin/nano-hydroxyapatite (PVA/SF/n …

Preparation of Nanoparticle‐Containing Ring‐Implanted Poly (Vinyl Alcohol) Contact Lens for Sustained Release of Hyaluronic Acid

E Akbari, R Imani, P Shokrollahi… - Macromolecular …, 2021 - Wiley Online Library
Here, a novel ring‐implanted poly vinyl alcohol (PVA) contact lens (CL) is fabricated and
evaluated as a therapeutic CL with potential of sustained release of hyaluronic acid (HA) …

Reinforced polyaniline/polyvinyl alcohol conducting hydrogel from a freezing–thawing method as self-supported electrode for supercapacitors

H Huang, J Yao, L Li, F Zhu, Z Liu, X Zeng, X Yu… - Journal of materials …, 2016 - Springer
In the present work, by using the in situ polymerization of aniline in acidic aqueous solution
of PVA and freezing–thawing method, the reinforced conducting polymer hydrogel of …

3-Chloro-3-methyl-2, 6-diarylpiperidin-4-ones as anti-cancer agents: synthesis, biological evaluation, molecular docking, and in silico ADMET prediction

A Ramalingam, N Mustafa, WJ Chng, M Medimagh… - Biomolecules, 2022 - mdpi.com
Piperidine pharmacophore-containing compounds have demonstrated therapeutic efficacy
against a range of diseases and are now being investigated in cancer. A series of 3-chloro-3 …

Interactive deformable electroluminescent devices enabled by an adaptable hydrogel system with optical/photothermal/mechanical tunability

Z Hou, S Zeng, K Shen, PR Healey, HJ Schipper… - Materials …, 2023 - pubs.rsc.org
Deformable electroluminescent devices (DELDs) with mechanical adaptability are promising
for new applications in smart soft electronics. However, current DELDs still present some …