Cardiovascular diseases are the leading cause of death worldwide. Therefore, the discovery
of induced pluripotent stem cells (iPSCs) and the subsequent generation of human induced …

The adult heart is a vital and highly specialized organ of the human body, with limited
capability of self-repair and regeneration in case of injury or disease. Engineering …

The human heart has the least regenerative capabilities among tissues and organs, and
heart disease continues to be a leading cause of mortality in the industrialized world with …

Potassium inward rectifier channel Kir2 is an important component of terminal cardiac
repolarization and resting membrane stability. This functionality is part of balanced cardiac …

Cardiovascular diseases are caused by hereditary factors, environmental conditions, and
medication-related issues. On the other hand, the cardiotoxicity of drugs should be …

Relevant, predictive normal, or disease model systems are of vital importance for drug
development. The difference between nonhuman models and humans could contribute to …

Disease modeling using human-induced pluripotent stem cell-derived cardiomyocytes
(hiPSC-CMs) has both challenges and promise. While patient-derived iPSC-CMs provide a …

Human induced pluripotent stem cells (hiPSC) possess significant therapeutic potential due
to their high self-renewal capability and potential to differentiate into specialized cells such …

The neuronal ceroid lipofuscinoses (NCLs) are mostly seen as diseases affecting the central
nervous system, but there is accumulating evidence that they have co-morbidities outside …

Highlights•Overview of analytics for characterization of stem cells' critical quality
attributes.•Highlight the main challenges for definition of stem cell potency.•Outline the role …