As resident macrophages of the CNS, microglia are critical immune effectors of inflammatory
lesions and associated neural dysfunctions. In multiple sclerosis (MS) and its animal …

The complement system, an essential part of the innate immune system, is composed of a
group of secreted and membrane proteins that collectively participate in maintaining the …

Growing evidence from cerebrospinal fluid samples and post-mortem brain tissue from
individuals with multiple sclerosis (MS) and rodent models indicates that the meninges have …

Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous
system (CNS) characterized by varying degrees of secondary neurodegeneration. Retinal …

Abstract Parvalbumin-positive (PV+) γ-aminobutyric acid (GABA) interneurons are critically
involved in producing rapid network oscillations and cortical microcircuit computations, but …

Synaptic plasticity is the fundamental cellular mechanism of learning and memory, but
recent research reveals that myelin-forming glia, oligodendrocytes (OL), are also involved …

C1q is a crucial component of the complement system, which is activated through the
classical pathway to perform non-specific immune functions, serving as the first line of …

Abstract Parvalbumin-expressing (PV+) basket cells are fast-spiking inhibitory interneurons
that exert critical control over local circuit activity and oscillations. PV+ axons are often …

Clinical, pathological, and imaging evidence in multiple sclerosis (MS) suggests that a
smoldering inflammatory activity is present from the earliest stages of the disease and …

Background Microglia have been implicated in the pathophysiology of major depressive
disorder (MDD), but information on biological mechanisms is limited. Therefore, we …