[HTML][HTML] Preclinical models and evaluation criteria of prostatitis

H He, H Luo, H Xu, B Qian, X Zou, G Zhang… - Frontiers in …, 2023 - frontiersin.org
Prostatitis is a common urological condition that affects almost half of all men at some point
in their life. The prostate gland has a dense nerve supply that contributes to the production of …

[HTML][HTML] Experimental rodent models of chronic prostatitis and evaluation criteria

W Wang, M Naveed, MMFA Baig, M Abbas… - Biomedicine & …, 2018 - Elsevier
Chronic prostatitis (CP) is a common disease in urology and can be develop in all age
groups. It is more commonly seen in men over the age of 50. It's cure rate is low, the …

[HTML][HTML] The role of inflammatory cytokines and ERK1/2 signaling in chronic prostatitis/chronic pelvic pain syndrome with related mental health disorders

C Hu, H Yang, Y Zhao, X Chen, Y Dong, L Li… - Scientific Reports, 2016 - nature.com
Mental health disorders (MHD) in chronic prostatitis/chronic pelvic pain syndrome
(CP/CPPS) have been widely studied. However, the underlying role of inflammatory …

Tryptase-PAR2 axis in experimental autoimmune prostatitis, a model for chronic pelvic pain syndrome

K Roman, JD Done, AJ Schaeffer, SF Murphy… - Pain, 2014 - journals.lww.com
The tryptase-PAR2 axis is a crucial mediator of pelvic pain in experimental autoimmune
prostatitis and may play an important role in the pathogenesis of chronic prostatitis/chronic …

[HTML][HTML] Development and validation of an animal model of prostate inflammation-induced chronic pelvic pain: evaluating from inflammation of the prostate to pain …

F Zeng, H Chen, J Yang, L Wang, Y Cui, X Guan… - PLoS …, 2014 - journals.plos.org
Background Chronic prostatitis/Chronic pelvic pain syndrome (CP/CPPS) is the most
common type of prostatitis. Due to the lack of a suitable animal model partly, the …

Interventions to chronic prostatitis/Chronic pelvic pain syndrome treatment. Where are we standing and what's next?

MA Santharam, FU Khan, M Naveed, U Ali… - European Journal of …, 2019 - Elsevier
Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) is a frustrating syndrome. The
pathogenesis and state of the art treatment of CP/CPPS are not known. A wide variety of …

Experimental autoimmune prostatitis: different antigens induction and antigen-specific therapy

Y Liu, J Wazir, M Tang, R Ullah, Y Chen, T Chen… - … Urology and Nephrology, 2021 - Springer
Purpose Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has uncertain etiology
and lacks effective treatment. Autoimmunity is an important pathogeny, and experimental …

A novel mouse model of chronic prostatitis/chronic pelvic pain syndrome induced by immunization of special peptide fragment with aluminum hydroxide adjuvant

FU Khan, AU Ihsan, W Nawaz, MZ Khan, M Yang… - Immunology …, 2017 - Elsevier
Objectives CP/CPPS is a commonly observed distress in male patients. Because of its little-
known etiology, no effective therapy has been developed which has promising outcomes …

Establishment of a rat model of chronic Prostatitis/Chronic Pelvic Pain Syndrome (CP/CPPS) induced by immunization with a novel peptide T2

AU Ihsan, FU Khan, W Nawaz, MZ Khan… - Biomedicine & …, 2017 - Elsevier
Background The exact etiological mechanism of Chronic Prostatitis/chronic pelvic pain
syndrome (CP/CPPS) is still unclear however autoimmunity is the most valid theory. We …

Targeting CXCL12/CXCR4 signaling with AMD3100 might selectively suppress CXCR4+ T-cell chemotaxis leading to the alleviation of chronic prostatitis

M Zhang, Y Liu, J Chen, L Chen, L Zhang… - Journal of …, 2022 - Taylor & Francis
Background Chronic nonbacterial prostatitis (CNP) has a high incidence, low cure rate, and
unclear pathogenesis. Here, we aimed to systematically identify effective diagnostic and …