Role of aldo‐keto reductase family 1 member B1 (AKR1B1) in the cancer process and its therapeutic potential
R Khayami, SR Hashemi… - Journal of cellular and …, 2020 - Wiley Online Library
The role of aldo‐keto reductase family 1 member B1 (AKR1B1) in cancer is not totally clear
but growing evidence is suggesting to have a great impact on cancer progression. AKR1B1 …
but growing evidence is suggesting to have a great impact on cancer progression. AKR1B1 …
A systematic review and quantitative assessment of methylation biomarkers in fecal DNA and colorectal cancer and its precursor, colorectal adenoma
R Liu, X Su, Y Long, D Zhou, X Zhang, Z Ye… - … Research/Reviews in …, 2019 - Elsevier
Colorectal cancer (CRC) arises from accumulated genetic and epigenetic alterations, which
provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA …
provide the possibility to identify tumor-specific biomarkers by analyzing fecal DNA …
Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
M Andrea, T Weinschenk, V Goldfinger… - US Patent …, 2019 - Google Patents
The present invention relates to peptides, proteins, nucleic acids and cells for use in
immunotherapeutic methods. In particular, the present invention relates to the immuno …
immunotherapeutic methods. In particular, the present invention relates to the immuno …
Peptides and combination of peptides for use in immunotherapy against small cell lung cancer and other cancers
A Mahr, T Weinschenk, V Goldfinger, O Schoor… - 2018 - Google Patents
ZRKFYGHZFMAOKI-QMGMOQQFSA-N tgfbeta Chemical compound C ([C@ H](NC (=
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …
O)[C@ H](C (C) C) NC (= O) CNC (= O)[C@ H](CCC (O)= O) NC (= O)[C@ H](CCCNC (N) …
[HTML][HTML] OPCML is frequently methylated in human colorectal cancer and its restored expression reverses EMT via downregulation of smad signaling
C Li, L Tang, L Zhao, L Li, Q Xiao, X Luo… - American Journal of …, 2015 - ncbi.nlm.nih.gov
Emerging evidence has indicated that the expression of OPCML gene is frequently altered
in a variety of cancers. We previously demonstrated that the OPCML gene is a target of …
in a variety of cancers. We previously demonstrated that the OPCML gene is a target of …
Gene promoter and exon DNA methylation changes in colon cancer development–mRNA expression and tumor mutation alterations
B Molnár, O Galamb, B Péterfia, B Wichmann, I Csabai… - BMC cancer, 2018 - Springer
Background DNA mutations occur randomly and sporadically in growth-related genes,
mostly on cytosines. Demethylation of cytosines may lead to genetic instability through …
mostly on cytosines. Demethylation of cytosines may lead to genetic instability through …
Hinokitiol induces DNA demethylation via DNMT1 and UHRF1 inhibition in colon cancer cells
JS Seo, YH Choi, JW Moon, HS Kim, SH Park - BMC cell biology, 2017 - Springer
Background DNA hypermethylation is a key epigenetic mechanism for the silencing of many
genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce …
genes in cancer. Hinokitiol, a tropolone-related natural compound, is known to induce …
A novel lncRNA SOX2OT promotes the malignancy of human colorectal cancer by interacting with miR-194-5p/SOX5 axis
Y Feng, Y Xu, Y Gao, Y Chen, X Wang, Z Chen - Cell Death & Disease, 2021 - nature.com
Long noncoding RNAs (lncRNAs) show emerging roles in colorectal cancer (CRC)
development and are considered to be involved in the potential mechanism of tumor …
development and are considered to be involved in the potential mechanism of tumor …
A new role for the mitochondrial pro-apoptotic protein SMAC/Diablo in phospholipid synthesis associated with tumorigenesis
A Paul, Y Krelin, T Arif, R Jeger, V Shoshan-Barmatz - Molecular Therapy, 2018 - cell.com
The mitochondrial pro-apoptotic protein SMAC/Diablo participates in apoptosis by
negatively regulating IAPs and activating caspases, thus encouraging apoptosis …
negatively regulating IAPs and activating caspases, thus encouraging apoptosis …
[HTML][HTML] Identifying potential DNA methylation markers in early-stage colorectal cancer
X Zhang, S Wan, Y Yu, W Ruan, H Wang, L Xu… - Genomics, 2020 - Elsevier
Colorectal cancer (CRC) is the second leading malignancy worldwide. Accurate screening
is pivotal to early CRC detection, yet current screening modality involves invasive …
is pivotal to early CRC detection, yet current screening modality involves invasive …