CRISPR interference (CRISPRi) and CRISPR activation (CRISPRa) have become
ubiquitous approaches to control gene expression in bacteria due to their simple design and …

Streptococcus pneumoniae is the most common cause of community-acquired pneumonia,
and one of the main pathogens responsible for otitis media infections in children. Amoxicillin …

Streptococcus pneumoniae is a bacterium that causes serious infections, including
pneumonia. The limited range of available vaccines and the rise of antibiotic-resistant …

Bacterial cells are known to produce inhibitors of cell division in response to stress
responses and developmental programs. Knowledge of the underlying molecular …

Antibiotic resistance and tolerance remain a major problem for the treatment of
staphylococcal infections. Identifying genes that influence antibiotic susceptibility could open …

Advances in sequencing technologies have enabled unprecedented insights into bacterial
genome composition and dynamics. However, the disconnect between the rapid acquisition …

Antimicrobial tolerance is the ability of a microbial population to survive, but not proliferate,
during antimicrobial exposure. Significantly, it has been shown to precede the development …

Bacteria are known to cope with amino acid starvation by the stringent response signaling
system, which is mediated by the accumulation of the (p) ppGpp alarmones when …

Recycling of undecaprenol pyrophosphate is critical to regenerate the pool of undecaprenol
monophosphate required for cell wall biosynthesis. Undecaprenol pyrophosphate is …

Antimicrobial tolerance is the ability of a microbial population to survive, but not proliferate,
during antimicrobial exposure. Significantly, it has been shown to precede the development …