Myxomatous degenerative mitral valve disease (MMVD) is a common heart disease in dogs.
Although several morphological similarities occur between human and canine MMVD …

Little is known about the molecular abnormalities associated with canine degenerative mitral
valve disease (DMVD). The pathology of DMVD involves the differentiation and activation of …

Objective—To describe structural changes in the left atrioventricular (mitral) valve complex
of dogs with endocardiosis by use of scanning electron microscopy. Animals—5 clinically …

Background: Increased serotonin (5HT) signaling has been implicated in valvular disease of
humans and animals, including canine degenerative mitral valve disease (DMVD). High …

Hypothesis/Objectives Altered serotonin (5‐hydroxytryptamine, 5 HT) signaling is postulated
in development and progression of canine myxomatous mitral valve disease (MMVD). Little …

The pathogenesis of chronic valvular disease (CVD) in dogs remains unclear, but activation
and proliferation of valvular stromal cells (VSC) and their transdifferentiation into …

OBJECTIVE: The aim of this study was to describe the clinical, functional, and morphologic
characteristics of platelets in Cavalier King Charles Spaniel dogs (Cavaliers). MATERIALS …

Objective To evaluate hemostatic changes following experimental acute hemorrhage in
dogs using traditional coagulation tests (eg, platelet count, prothrombin time [PT], and …

Mitral regurgitation (MR) is a common valvular lesion frequently caused by mitral valve
prolapse (MVP). Surgical intervention in MVP patients with significant MR is predicated on …

With aggregometry, increased platelet activity has been reported in Cavalier King Charles
Spaniels (CKCS) without mitral regurgitation (MR). In contrast, dogs with MR have been …