Blood–brain barrier-on-a-chip: Microphysiological systems that capture the complexity of the blood–central nervous system interface

DTT Phan, RHF Bender… - Experimental …, 2017 - journals.sagepub.com
The blood–brain barrier is a dynamic and highly organized structure that strictly regulates
the molecules allowed to cross the brain vasculature into the central nervous system. The …

Endothelial sprouting, proliferation, or senescence: tipping the balance from physiology to pathology

S Mühleder, M Fernández-Chacón… - Cellular and Molecular …, 2021 - Springer
Therapeutic modulation of vascular cell proliferation and migration is essential for the
effective inhibition of angiogenesis in cancer or its induction in cardiovascular disease. The …

Vis-à-vis: a focus on genetic features of cerebral cavernous malformations and brain arteriovenous malformations pathogenesis

C Scimone, L Donato, S Marino, C Alafaci… - Neurological …, 2019 - Springer
Cerebrovascular malformations include a wide range of blood vessel disorders affecting
brain vasculature. Neuroimaging differential diagnosis can result unspecific due to similar …

[HTML][HTML] An updated review on the genetics of arteriovenous malformations

K Maddy, A Chalamgari, O Ariwodo… - Gene & protein in …, 2023 - accscience.com
Arteriovenous malformations (AVM) are congenital malformations of the cerebral
vasculature resulting in pathological shunting of blood through dilated arteries and veins …

miR-18a inhibits BMP4 and HIF-1α normalizing brain arteriovenous malformations

NI Marín-Ramos, TZ Thein, KB Ghaghada… - Circulation …, 2020 - Am Heart Assoc
Rationale: Brain arteriovenous malformations (AVMs) are abnormal tangles of vessels
where arteries and veins directly connect without intervening capillary nets, increasing the …

Congenital retinal macrovessel and the association of retinal venous malformations with venous malformations of the brain

F Pichi, KB Freund, A Ciardella, M Morara… - JAMA …, 2018 - jamanetwork.com
Importance Congenital retinal macrovessel (CRM) is a rarely reported venous malformation
of the retina that is associated with venous anomalies of the brain. Objective To study the …

Overview of the current concepts in the management of arteriovenous malformations of the brain

AKA Unnithan - Postgraduate Medical Journal, 2020 - academic.oup.com
Background There is a lack of consensus in the management of arteriovenous
malformations (AVMs) of the brain since ARUBA (A Randomised trial of Unruptured Brain …

Understanding the pathogenesis of brain arteriovenous malformation: genetic variations, epigenetics, signaling pathways, and immune inflammation

S Wang, X Deng, Y Wu, Y Wu, S Zhou, J Yang… - Human Genetics, 2023 - Springer
Brain arteriovenous malformation (BAVM) is a rare but serious cerebrovascular disease
whose pathogenesis has not been fully elucidated. Studies have found that epigenetic …

Germline mutation enrichment in pathways controlling endothelial cell homeostasis in patients with brain arteriovenous malformation: implication for molecular …

C Scimone, F Granata, M Longo, E Mormina… - International Journal of …, 2020 - mdpi.com
Brain arteriovenous malformation (bAVM) is a congenital defect affecting brain
microvasculature, characterized by a direct shunt from arterioles to venules. Germline …

[HTML][HTML] Treatments of unruptured brain arteriovenous malformations: A systematic review and meta-analysis

R Liu, Y Zhan, J Piao, Z Yang, Y Wei, P Liu, X Chen… - Medicine, 2021 - journals.lww.com
Background: The best therapeutic option for unruptured brain arteriovenous malformations
(bAVMs) patients is disputed. Objective: To assess the occurrence of obliteration and …