Interferon-α (IFNα) and IFNβ, collectively known as type I IFNs, are the major effector
cytokines of the host immune response against viral infections. However, the production of …

Leishmaniasis is a parasitic disease of humans, highly prevalent in parts of the tropics,
subtropics, and southern Europe. The disease mainly occurs in three different clinical forms …

Because of the large preexisting antigenic load and immunosuppressive environment within
a tumor, inducing therapeutically useful antitumor immunity in cancer patients requires the …

Chronic plaque psoriasis is a common debilitating skin disease. The identification of the
pathogenic role of the TNF/IL-23/TH17 pathway has enabled the development of targeted …

Neutrophils are professional phagocytes that migrate early, in high number, to the infection
sites. Our study has analyzed how neutrophils cross-present antigens and influence CD8+ T …

Interferons-α (IFN-α) are pleiotropic cytokines belonging to type I IFNs, extensively used in
the treatment of patients with some types of cancer and viral disease. IFN-α can affect tumor …

Since the seminal discovery of dendritic cells (DCs) by Steinman and Cohn in 1973, there
has been an ongoing debate to what extent macrophages and DCs are related and perform …

Dendritic cells (DCs) are professional antigen presenting cells displaying the unique
capability to activate naïve T cells. DCs react to pathogen encounter also by the production …

Induction of potent tumor-specific cytotoxic T-cell responses is a fundamental objective in
anticancer therapeutic strategies. This event requires that antigen-presenting cells present …

Allergic contact hypersensitivity (CHS) is a T cell–mediated inflammatory skin disease.
Interleukin (IL)-12 is considered to be important in the generation of the allergen-specific T …