Neurotransmission between neurons, which can occur over the span of a few milliseconds,
relies on the controlled release of small molecule neurotransmitters, many of which are …

Herein, we review the multifaceted roles of proline in cell biology. This peculiar cyclic imino
acid is:(i) A main precursor of extracellular collagens (the most abundant human proteins) …

Interest in how proline contributes to cancer biology is expanding because of the emerging
role of a novel proline metabolic cycle in cancer cell survival, proliferation, and metastasis …

The neutral amino acid transporter subfamily that consists of six members, consecutively
SLC6A15–SLC620, also called orphan transporters, represents membrane, sodium …

Synaptic plasticity alters the strength of information flow between presynaptic and
postsynaptic neurons and thus modifies the likelihood that action potentials in a presynaptic …

Proline has important roles in multiple biological processes such as cellular bioenergetics,
cell growth, oxidative and osmotic stress response, protein folding and stability, and redox …

Using a systematic, whole-genome analysis of enhancer activity of human-specific
endogenous retroviral inserts (hsERVs), we identified an element, hsERV PRODH, that acts …

Abstract Background and Hypothesis Schizophrenia is associated with altered energy
metabolism, but the cause and potential impact of these metabolic changes remain …

Schizophrenia is a debilitating mental disorder. Currently, the lack of disease biomarkers to
support objective laboratory tests constitutes a bottleneck in the clinical diagnosis of …

Proline dehydrogenase (PRODH), which degrades L-proline, resides within the
schizophrenia-linked 22q11. 2 deletion suggesting a role in disease. Supporting this …