Imaging and fluid biomarkers in frontotemporal dementia

LH Meeter, LD Kaat, JD Rohrer… - Nature Reviews …, 2017 - nature.com
Frontotemporal dementia (FTD), the second most common type of presenile dementia, is a
heterogeneous neurodegenerative disease characterized by progressive behavioural …

Speech and language impairments in behavioral variant frontotemporal dementia: a systematic review

A Geraudie, P Battista, AM García, IE Allen… - Neuroscience & …, 2021 - Elsevier
Although behavioral variant frontotemporal dementia (bvFTD) is classically defined by
behavioral and socio-emotional changes, impairments often extend to other cognitive …

Distribution of dipeptide repeat proteins in cellular models and C9orf72 mutation cases suggests link to transcriptional silencing

MH Schludi, S May, FA Grässer, K Rentzsch… - Acta …, 2015 - Springer
A massive expansion of a GGGGCC repeat upstream of the C9orf72 coding region is the
most common known cause of amyotrophic lateral sclerosis and frontotemporal dementia …

Harmonization of brain diffusion MRI: concepts and methods

MS Pinto, R Paolella, T Billiet, P Van Dyck… - Frontiers in …, 2020 - frontiersin.org
MRI diffusion data suffers from significant inter-and intra-site variability, which hinders multi-
site and/or longitudinal diffusion studies. This variability may arise from a range of factors …

Genetics of frontotemporal dementia

DA Olszewska, R Lonergan, EM Fallon… - Current neurology and …, 2016 - Springer
Frontotemporal dementia (FTD) is the second most common cause of dementia following
Alzheimer's disease (AD). Between 20 and 50% of cases are familial. Mutations in MAPT …

[HTML][HTML] Network degeneration and dysfunction in presymptomatic C9ORF72 expansion carriers

SE Lee, AC Sias, ML Mandelli, JA Brown, AB Brown… - NeuroImage: Clinical, 2017 - Elsevier
Hexanucleotide repeat expansions in C9ORF72 are the most common known genetic cause
of familial and sporadic frontotemporal dementia and amyotrophic lateral sclerosis. Previous …

Apathy and impulsivity in frontotemporal lobar degeneration syndromes

CJ Lansdall, ITS Coyle-Gilchrist, PS Jones… - Brain, 2017 - academic.oup.com
Apathy and impulsivity are common and disabling consequences of frontotemporal lobar
degeneration. They cause substantial carer distress, but their aetiology remains elusive …

Diffusion magnetic resonance imaging-based biomarkers for neurodegenerative diseases

K Kamagata, C Andica, A Kato, Y Saito… - International Journal of …, 2021 - mdpi.com
There has been an increasing prevalence of neurodegenerative diseases with the rapid
increase in aging societies worldwide. Biomarkers that can be used to detect pathological …

Neuroimaging in dementia

AM Staffaroni, FM Elahi, D McDermott… - Seminars in …, 2017 - thieme-connect.com
Although the diagnosis of dementia still is primarily based on clinical criteria, neuroimaging
is playing an increasingly important role. This is in large part due to advances in techniques …

Neurofilament light chain as a biomarker, and correlation with magnetic resonance imaging in diagnosis of CNS-related disorders

Z Alirezaei, MH Pourhanifeh, S Borran, M Nejati… - Molecular …, 2020 - Springer
The search for diagnostic and prognostic biomarkers for neurodegenerative conditions is of
high importance, since these disorders may present difficulties in differential diagnosis …