HDL-targeted therapies: progress, failures and future

BA Kingwell, MJ Chapman, A Kontush… - Nature reviews Drug …, 2014 - nature.com
Since the discovery in the 1970s that plasma levels of high-density lipoprotein cholesterol
(HDL-C) are inversely associated with cardiovascular outcome, it has been postulated that …

Update on the molecular biology of dyslipidemias

I Ramasamy - Clinica chimica acta, 2016 - Elsevier
Dyslipidemia is a commonly encountered clinical condition and is an important determinant
of cardiovascular disease. Although secondary factors play a role in clinical expression …

[HTML][HTML] Lecithin: cholesterol acyltransferase: old friend or foe in atherosclerosis?

S Kunnen, M Van Eck - Journal of lipid research, 2012 - ASBMB
Lecithin: cholesterol acyltransferase (LCAT) is a key enzyme that catalyzes the esterification
of free cholesterol in plasma lipoproteins and plays a critical role in high-density lipoprotein …

HDL dysfunction in diabetes: causes and possible treatments

D Farbstein, AP Levy - Expert review of cardiovascular therapy, 2012 - Taylor & Francis
HDL is known to be inversely correlated with cardiovascular disease due to its diverse
antiatherogenic functions. These functions include cholesterol efflux and reverse cholesterol …

HDL cholesterol metabolism and the risk of CHD: new insights from human genetics

C Vitali, SA Khetarpal, DJ Rader - Current cardiology reports, 2017 - Springer
Abstract Purpose of Review Elevated high-density lipoprotein cholesterol levels in the blood
(HDL-C) represent one of the strongest epidemiological surrogates for protection against …

Novel HDL-directed pharmacotherapeutic strategies

EM Degoma, DJ Rader - Nature Reviews Cardiology, 2011 - nature.com
The burden of atherothrombotic cardiovascular disease remains high despite currently
available optimum medical therapy. To address this substantial residual risk, the …

Association between vegetarian diets and cardiovascular risk factors in non-Hispanic white participants of the Adventist Health Study-2

S Matsumoto, WL Beeson, DJ Shavlik… - Journal of nutritional …, 2019 - cambridge.org
The association between dietary patterns and CVD risk factors among non-Hispanic whites
has not been fully studied. Data from 650 non-Hispanic white adults who participated in one …

Role of LCAT in atherosclerosis

A Ossoli, S Simonelli, C Vitali… - … of atherosclerosis and …, 2016 - jstage.jst.go.jp
Lecithin: cholesterol acyltransferase (LCAT), first identified by Glomset1), is a lipoprotein-
associated enzyme responsible for the synthesis of most of the plasma cholesteryl esters …

Lecithin: cholesterol acyltransferase, high-density lipoproteins, and atheroprotection in humans

L Calabresi, G Franceschini - Trends in cardiovascular medicine, 2010 - Elsevier
The lecithin: cholesterol acyltransferase (LCAT) enzyme is responsible for the synthesis of
cholesteryl esters in human plasma. Lecithin: cholesterol acyltransferase is a critical enzyme …

Flipped C-terminal ends of apoA1 promote ABCA1-dependent cholesterol efflux by small HDLs

Y He, C Pavanello, PM Hutchins, C Tang… - Circulation, 2024 - Am Heart Assoc
BACKGROUND: Cholesterol efflux capacity (CEC) predicts cardiovascular disease
independently of high-density lipoprotein (HDL) cholesterol levels. Isolated small HDL …