Alongside the liver, white adipose tissue (WAT) is critical in regulating systemic energy
homeostasis. Although each organ has its specialised functions, they must work …

Obesity is a worldwide epidemic that predisposes individuals to cardiometabolic
complications, such as type 2 diabetes mellitus (T2DM) and nonalcoholic fatty liver disease …

Insulin resistance is a key mediator of obesity-related cardiometabolic disease, yet the
mechanisms underlying this link remain obscure. Using an integrative genomic approach …

Peroxisome proliferator-activated receptors are expressed in many tissues, including
adipocytes, hepatocytes, muscles and endothelial cells; however, the affinity depends on the …

Obesity has become a major public health problem. Given the current increase in life
expectancy, the prevalence of obesity also raises steadily among older age groups. The …

Peroxisome proliferator-activated receptor gamma (PPARγ) has been the focus of intense
research because ligands for this receptor have emerged as potent insulin sensitizers used …

Thiazolidinediones (TZDs) are potent insulin sensitizers that act through the nuclear
receptor peroxisome proliferator-activated receptor-γ (PPARγ) and are highly effective oral …

Agonists of the nuclear receptor PPARγ are therapeutically used to combat hyperglycaemia
associated with the metabolic syndrome and type 2 diabetes. In spite of being effective in …

Liquid chromatography-mass spectrometry (LC-MS)-based lipidomics has undergone
dramatic developments over the past decade. This review focuses on state of the art in LC …

Background Mass spectrometry (MS) coupled with online separation methods is commonly
applied for differential and quantitative profiling of biological samples in metabolomic as well …