Fighting antibiotic resistance—strategies and (pre) clinical developments to find new antibacterials
S Walesch, J Birkelbach, G Jézéquel, FPJ Haeckl… - EMBO …, 2023 - embopress.org
Antibacterial resistance is one of the greatest threats to human health. The development of
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
new therapeutics against bacterial pathogens has slowed drastically since the approvals of …
[HTML][HTML] Towards the sustainable discovery and development of new antibiotics
An ever-increasing demand for novel antimicrobials to treat life-threatening infections
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
caused by the global spread of multidrug-resistant bacterial pathogens stands in stark …
[HTML][HTML] Expanding the substrate scope of pyrrolysyl-transfer RNA synthetase enzymes to include non-α-amino acids in vitro and in vivo
R Fricke, CV Swenson, LT Roe, NX Hamlish, B Shah… - Nature …, 2023 - nature.com
The absence of orthogonal aminoacyl-transfer RNA (tRNA) synthetases that accept non-l-α-
amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined …
amino acids is a primary bottleneck hindering the in vivo translation of sequence-defined …
Iterative synthesis of 1, 3-polyboronic esters with high stereocontrol and application to the synthesis of bahamaolide A
SG Aiken, JM Bateman, HH Liao, A Fawcett… - Nature Chemistry, 2023 - nature.com
Polyketide natural products often contain common repeat motifs, for example, propionate,
acetate and deoxypropionate, and so can be synthesized by iterative processes. We report …
acetate and deoxypropionate, and so can be synthesized by iterative processes. We report …
Systems and synthetic biology to elucidate secondary metabolite biosynthetic gene clusters encoded in Streptomyces genomes
Covering: 2010 to 2020 Over the last few decades, Streptomyces have been extensively
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
investigated for their ability to produce diverse bioactive secondary metabolites. Recent …
[HTML][HTML] Deep learning approaches for natural product discovery from plant endophytic microbiomes
Plant microbiomes are not only diverse, but also appear to host a vast pool of secondary
metabolites holding great promise for bioactive natural products and drug discovery. Yet …
metabolites holding great promise for bioactive natural products and drug discovery. Yet …
Platform-based product development in the process industry: a systematic literature review
Platform-based product development has been applied extensively in discrete
manufacturing industry to accommodate changing market demands. Nevertheless, while …
manufacturing industry to accommodate changing market demands. Nevertheless, while …
[HTML][HTML] Streptomyces as Microbial Chassis for Heterologous Protein Expression
Heterologous production of recombinant proteins is gaining increasing interest in
biotechnology with respect to productivity, scalability, and wide applicability. The members …
biotechnology with respect to productivity, scalability, and wide applicability. The members …
Biosynthetic cyclization catalysts for the assembly of peptide and polyketide natural products
ML Adrover‐Castellano, JJ Schmidt… - …, 2021 - Wiley Online Library
Many biologically active natural products are synthesized by nonribosomal peptide
synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These …
synthetases (NRPSs), polyketide synthases (PKSs) and their hybrids. These …
Development of genetically encoded biosensors for reporting the methyltransferase-dependent biosynthesis of semisynthetic macrolide antibiotics
Clarithromycin is an improved semisynthetic analogue of the naturally occurring macrolide,
erythromycin. The subtle modification of a methyl group on the C-6 hydroxyl group endows …
erythromycin. The subtle modification of a methyl group on the C-6 hydroxyl group endows …