Importance A 2016 review for the US Preventive Services Task Force (USPSTF) found use
of statins for primary prevention of cardiovascular disease (CVD) was associated with …

Objective To assess the associations between statins and adverse events in primary
prevention of cardiovascular disease and to examine how the associations vary by type and …

Background: To quantify the association between effects of interventions on carotid intima-
media thickness (cIMT) progression and their effects on cardiovascular disease (CVD) risk …

Importance Cardiovascular disease (CVD), the leading cause of mortality and morbidity in
the United States, may be potentially preventable with statin therapy. Objective To …

Background Reducing high blood cholesterol, a risk factor for cardiovascular disease (CVD)
events in people with and without a past history of coronary heart disease (CHD) is an …

Background: Whether menopausal hormone therapy (MHT) protects against cardiovascular
disease (CVD) remains unclear. Objective: To assess atherosclerosis progression and CVD …

Objectives To investigate whether statins reduce all cause mortality and major coronary and
cerebrovascular events in people without established cardiovascular disease but with …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

Echocardiography is one of the most commonly performed noninvasive diagnostic tests in
patients with known or suspected cardiovascular diseases. Echocardiography provides …

ContextLowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of
recurrent coronary heart disease in middle-aged men. However, this effect has been …