Striatal insights: a cellular and molecular perspective on repetitive behaviors in pathology

CL Burton, A Longaretti, A Zlatanovic… - Frontiers in Cellular …, 2024 - frontiersin.org
Animals often behave repetitively and predictably. These repetitive behaviors can have a
component that is learned and ingrained as habits, which can be evolutionarily …

ErbB inhibition rescues nigral dopamine neuron hyperactivity and repetitive behaviors in a mouse model of fragile X syndrome

SL D'Addario, E Rosina, M Massaro Cenere… - Molecular …, 2024 - nature.com
Repetitive stereotyped behaviors are core symptoms of autism spectrum disorders (ASD)
and fragile X syndrome (FXS), the prevalent genetic cause of intellectual disability and …

Light-Activatable, Cell-Type Specific Labeling of the Nascent Proteome

HT Evans, T Ko, MM Oliveira, A Yu… - ACS Chemical …, 2024 - ACS Publications
Elucidating the mechanisms by which protein synthesis contributes to complex biological
processes has remained a challenging endeavor. This is particularly true in the field of …

Behavioral, neurotransmitter and transcriptomic analyses in male and female Fmr1 KO mice

DM McCarthy, C Vied, MX Trupiano… - Frontiers in Behavioral …, 2024 - frontiersin.org
Introduction Fragile X syndrome is an inherited X-linked disorder associated with intellectual
disabilities that begin in childhood and last a lifetime. The symptoms overlap with autism …

State-dependent modulation of spiny projection neurons controls levodopa-induced dyskinesia in a mouse model of Parkinson's disease

S Zhai, Q Cui, D Wokosin, L Sun, T Tkatch… - bioRxiv, 2025 - biorxiv.org
In the later stages of Parkinson's disease (PD), patients often manifest levodopa-induced
dyskinesia (LID), compromising their quality of life. The pathophysiology underlying LID is …

Circuit mechanisms underlying sexually dimorphic outcomes of early life stress

C Jiang, I Ruiz-Sanchez, C Mei, C Pittenger - bioRxiv, 2024 - biorxiv.org
Stress during early life influences brain development and can affect social, motor, and
emotional processes. We describe a striking sex difference in the effects of early life stress …

Dysregulated acetylcholine-mediated dopamine neurotransmission in the eIF4E Tg mouse model of autism spectrum disorders.

J Carbonell-Roig, A Aaltonen, V Cartocci, A McGuirt… - bioRxiv, 2024 - biorxiv.org
Autism Spectrum Disorders (ASD) consist of diverse neurodevelopmental conditions where
core behavioral symptoms are critical for diagnosis. Altered dopamine neurotransmission in …

Aberrant TSC-Rheb axis in Oxytocin receptor+ cells mediate stress-induced anxiety

O Tabaka, S Lawal, RDR Triana, M Hou, A Fraser… - …, 2024 - pmc.ncbi.nlm.nih.gov
Stress is a major risk for the onset of several maladaptive processes including pathological
anxiety, a diffuse state of heightened apprehension over anticipated threats1. Pathological …

Role of Fragile X Ribonucleoprotein and Brain-Derived Neurotrophic Factor in Presynaptic Local Translation Regulation and Synaptic Plasticity

SC Kharod - 2024 - search.proquest.com
Protein synthesis is crucial for solidifying long-term memories, likely by fine tuning synaptic
changes. Recent findings indicate that disruptions in synaptic protein synthesis may serve …