Targeted protein degradation (TPD) provides unprecedented opportunities for drug
discovery. While the proteolysis-targeting chimera (PROTAC) technology has already …

Covalent inhibitors and other types of covalent modalities have seen a revival in the past two
decades, with a variety of new targeted covalent drugs having been approved in recent …

Sanshool, a naturally occurring molecule from Zanthoxylum xanthoxylum, is an essential
component preventing photodamage; however, inherent instabilities and the potential risk of …

Background Shikonin, a natural naphthoquinone compound, has a wide range of
pharmacological effects, but its anti-tumor effect and underlying mechanisms in bladder …

Selective modulation of autophagy is a promising therapeutic strategy, especially for cancer
treatment. However, the lack of specific autophagy inhibitors limits this strategy. The …

In the scope of targeted protein degradation (TPD), proteolysis-targeting chimeras
(PROTACs), leveraging the ubiquitin–proteasome system, have been extensively studied …

Autophagy, a crucial intracellular degradation process facilitated by lysosomes, plays a
pivotal role in maintaining cellular homeostasis. The elucidation of autophagy key genes …

Autophagy is a cellular process in which proteins and organelles are engulfed in
autophagosomal vesicles and transported to the lysosome/vacuole for degradation. Protein …

Hereditary spastic paraplegia (HSP) is a group of inherited neurodegenerative disorders
characterized by progressive lower limb spasticity and weakness. One subtype of HSP …

Autophagy is a highly conserved physiological process that maintains cellular homeostasis
by recycling cellular contents. Selective autophagy is based on the specificity of cargo …