Filament formation activates protease and ring nuclease activities of CRISPR SAVED-Lon
D Smalakyte, A Ruksenaite, G Sasnauskas… - bioRxiv, 2024 - biorxiv.org
To combat phage infection, type III CRISPR-Cas systems utilize cyclic oligoadenylates (cAn)
signaling to activate various auxiliary effectors, including the CRISPR-associated SAVED …
signaling to activate various auxiliary effectors, including the CRISPR-associated SAVED …
Understanding the mechanism of bacterial cGAS immunity and its co-evolution with phage
E Huiting - 2024 - escholarship.org
A fundamental strategy of eukaryotic anti-viral innate immunity involves the cGAS enzyme,
which synthesizes 2', 3'-cGAMP and activates a STING effector to limit viral replication …
which synthesizes 2', 3'-cGAMP and activates a STING effector to limit viral replication …