The importance of resistance to direct antiviral drugs in HCV infection in clinical practice
C Sarrazin - Journal of hepatology, 2016 - Elsevier
Treatment of chronic hepatitis C virus (HCV) infection with direct-acting antiviral agents
(DAA) is associated with high rates of sustained virologic response. Remaining factors …
(DAA) is associated with high rates of sustained virologic response. Remaining factors …
Viral quasispecies evolution
Evolution of RNA viruses occurs through disequilibria of collections of closely related mutant
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
spectra or mutant clouds termed viral quasispecies. Here we review the origin of the …
Naturally occurring mutations of SARS-CoV-2 main protease confer drug resistance to nirmatrelvir
The SARS-CoV-2 main protease (Mpro) is the drug target of Pfizer's oral drug nirmatrelvir.
The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential …
The emergence of SARS-CoV-2 variants with mutations in Mpro raised the alarm of potential …
NACSELD acute‐on‐chronic liver failure (NACSELD‐ACLF) score predicts 30‐day survival in hospitalized patients with cirrhosis
Several highly effective, interferon‐free, direct‐acting antiviral (DAA)‐based regimens are
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …
available for the treatment of chronic hepatitis C virus (HCV) infection. Despite impressive …
Nucleotide polymerase inhibitor sofosbuvir plus ribavirin for hepatitis C
EJ Gane, CA Stedman, RH Hyland… - … England Journal of …, 2013 - Mass Medical Soc
Background The standard treatment for hepatitis C virus (HCV) infection is interferon, which
is administered subcutaneously and can have troublesome side effects. We evaluated …
is administered subcutaneously and can have troublesome side effects. We evaluated …
Ten years of dengue drug discovery: progress and prospects
To combat neglected diseases, the Novartis Institute of Tropical Diseases (NITD) was
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
founded in 2002 through private–public funding from Novartis and the Singapore Economic …
Resistance to direct antiviral agents in patients with hepatitis C virus infection
C Sarrazin, S Zeuzem - Gastroenterology, 2010 - Elsevier
Chronic hepatitis C virus (HCV) infection is one of the major causes of cirrhosis,
hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard …
hepatocellular carcinoma, and liver failure that leads to transplantation. The current standard …
[HTML][HTML] KASL clinical practice guidelines: management of hepatitis C
Korean Association for the Study of the … - Clinical and …, 2016 - ncbi.nlm.nih.gov
Aims The Korean Association for the Study of the Liver (KASL) Practice Guidelines for
Management of Hepatitis C were first established in 2004, and revised in 2013, when direct …
Management of Hepatitis C were first established in 2004, and revised in 2013, when direct …
Nucleoside, nucleotide, and non-nucleoside inhibitors of hepatitis C virus NS5B RNA-dependent RNA-polymerase
Hepatitis C virus (HCV) infection is a global health problem that impacts approximately 180
million individuals. Of those initially infected with HCV approximately 80% will progress to …
million individuals. Of those initially infected with HCV approximately 80% will progress to …
Rapid emergence of protease inhibitor resistance in hepatitis C virus
About 170 million people worldwide are infected with hepatitis C virus (HCV). The current
standard therapy leads to sustained viral elimination in only~ 50% of the treated patients …
standard therapy leads to sustained viral elimination in only~ 50% of the treated patients …