The physical and biochemical properties of the extracellular matrix regulate cell fate
The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …
sugars that, in concert with bound soluble factors, comprise the acellular stromal …
Heparan sulfate: biosynthesis, structure, and function
JP Li, M Kusche-Gullberg - International review of cell and molecular …, 2016 - Elsevier
Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …
in the extracellular matrix of most animal tissues, having essential functions in development …
Heparan sulfate proteoglycans biosynthesis and post synthesis mechanisms combine few enzymes and few core proteins to generate extensive structural and …
Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …
Interactions between heparan sulfate and proteins—design and functional implications
Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …
animal tissues are essential in development and homeostasis, and variously implicated in …
The developmental roles of the extracellular matrix: beyond structure to regulation
KY Tsang, MCH Cheung, D Chan, KSE Cheah - Cell and tissue research, 2010 - Springer
Cells in multicellular organisms are surrounded by a complex three-dimensional
macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a …
macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a …
Coreceptor functions of cell surface heparan sulfate proteoglycans
K Hayashida, RS Aquino… - American Journal of …, 2022 - journals.physiology.org
Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …
triggering specific cellular responses. These interactions are frequently regulated by …
MicroRNA-218 regulates vascular patterning by modulation of Slit-Robo signaling
EM Small, LB Sutherland, KN Rajagopalan… - Circulation …, 2010 - Am Heart Assoc
Rationale: Establishment of a functional vasculature requires the interconnection and
remodeling of nascent blood vessels. Precise regulation of factors that influence endothelial …
remodeling of nascent blood vessels. Precise regulation of factors that influence endothelial …
Heparan sulfate proteoglycan–A common receptor for diverse cytokines
Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed
ubiquitously on the cell surface and in the extracellular matrix where they interact with a …
ubiquitously on the cell surface and in the extracellular matrix where they interact with a …
Chemical tumor biology of heparan sulfate proteoglycans
K Raman, B Kuberan - Current chemical biology, 2010 - ingentaconnect.com
Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression
allowing cancer cells to proliferate, escape from immune response, invade neighboring …
allowing cancer cells to proliferate, escape from immune response, invade neighboring …
Human genetic disorders and knockout mice deficient in glycosaminoglycan
S Mizumoto, S Yamada… - BioMed research …, 2014 - Wiley Online Library
Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …
monosaccharides by various glycosyltransferases and maturated by epimerases and …