The extracellular matrix is a complex network of hydrated macromolecular proteins and
sugars that, in concert with bound soluble factors, comprise the acellular stromal …

Heparan sulfate (HS) proteoglycans (PGs) are ubiquitously expressed on cell surfaces and
in the extracellular matrix of most animal tissues, having essential functions in development …

Glycosylation is a common and widespread post-translational modification that affects a
large majority of proteins. Of these, a small minority, about 20, are specifically modified by …

Heparan sulfate (HS) proteoglycans at cell surfaces and in the extracellular matrix of most
animal tissues are essential in development and homeostasis, and variously implicated in …

Cells in multicellular organisms are surrounded by a complex three-dimensional
macromolecular extracellular matrix (ECM). This matrix, traditionally thought to serve a …

Receptor-ligand interactions play an important role in many biological processes by
triggering specific cellular responses. These interactions are frequently regulated by …

Rationale: Establishment of a functional vasculature requires the interconnection and
remodeling of nascent blood vessels. Precise regulation of factors that influence endothelial …

Heparan sulfate proteoglycans (HSPG) are macromolecular glyco-conjugates expressed
ubiquitously on the cell surface and in the extracellular matrix where they interact with a …

Heparan sulfate proteoglycans (HSPGs) play vital roles in every step of tumor progression
allowing cancer cells to proliferate, escape from immune response, invade neighboring …

Glycosaminoglycans (GAGs) are constructed through the stepwise addition of respective
monosaccharides by various glycosyltransferases and maturated by epimerases and …