Background: An increasing number of studies suggest that diet plays an important role in
regulating aging processes and modulates the development of the most important age …

Background: It has been four decades since protein S-glutathionylation was proposed to
serve as a regulator of cell metabolism. Since then, this redox-sensitive covalent …

Cardiovascular disease (CVD) is a group of systemic disorders threatening human health
with complex pathogenesis, among which mitochondrial energy metabolism reprogramming …

Geroscience, an emerging discipline at the intersection of aging and disease, seeks to
understand the relationship between the aging process and pathogenesis of age-related …

Due to its nucleophilicity, the thiol group of cysteine is chemically very versatile. Hence,
cysteine often has important functions in a protein, be it as the active site or, in extracellular …

The endoplasmic reticulum (ER) plays a key role in the regulation of protein folding, lipid
synthesis, calcium homeostasis, and serves as a primary site of sphingolipid biosynthesis …

Mitochondria adapt to increased energy demands during muscle contraction by acutely
altering metabolite fluxes and substrate oxidation. With age, an impaired mitochondrial …

Mitochondrial complex I can produce large quantities of reactive oxygen species (ROS) by
reverse electron transfer (RET) from the ubiquinone (UQ) pool. Glutathionylation of complex …

Aging muscle experiences functional decline in part mediated by impaired mitochondrial
ADP sensitivity. Elamipretide (ELAM) rapidly improves physiological and mitochondrial …

Aging-related cardiovascular disease is influenced by multiple factors, with oxidative stress
being a key contributor. Aging-induced endoplasmic reticulum (ER) stress exacerbates …