Obesity and cancer: a current overview of epidemiology, pathogenesis, outcomes, and management

S Pati, W Irfan, A Jameel, S Ahmed, RK Shahid - Cancers, 2023 - mdpi.com
Simple Summary Obesity has been linked to several common cancers including breast,
colorectal, esophageal, kidney, gallbladder, uterine, pancreatic, and liver cancer. Obesity …

Signaling pathways in obesity: mechanisms and therapeutic interventions

X Wen, B Zhang, B Wu, H Xiao, Z Li, R Li… - Signal transduction and …, 2022 - nature.com
Obesity is a complex, chronic disease and global public health challenge. Characterized by
excessive fat accumulation in the body, obesity sharply increases the risk of several …

The key role of mitochondrial function in health and disease

I San-Millán - Antioxidants, 2023 - mdpi.com
The role of mitochondrial function in health and disease has become increasingly
recognized, particularly in the last two decades. Mitochondrial dysfunction as well as …

Vigorous intermittent lifestyle physical activity and cancer incidence among nonexercising adults: The UK Biobank Accelerometry Study

E Stamatakis, MN Ahmadi, CM Friedenreich… - JAMA …, 2023 - jamanetwork.com
Importance Vigorous physical activity (VPA) is a time-efficient way to achieve recommended
physical activity (PA) for cancer prevention, although structured longer bouts of VPA (via …

Associations of sedentary time and physical activity with adverse health conditions: Outcome-wide analyses using isotemporal substitution model

Z Cao, C Xu, P Zhang, Y Wang - EClinicalMedicine, 2022 - thelancet.com
Background As one of the most common lifestyles today, sedentary behaviour is a risk factor
for many health conditions. To inform potential behavioural guideline development, we …

Muscle-to-tumor crosstalk: The effect of exercise-induced myokine on cancer progression

Q Huang, M Wu, X Wu, Y Zhang, Y Xia - Biochimica et Biophysica Acta …, 2022 - Elsevier
Physical exercise has gradually become a focus in cancer treatment due to its pronounced
role in reducing cancer risk, enhancing therapeutic efficacy, and improving prognosis. In …

Chronic inflammation towards cancer incidence: A systematic review and meta-analysis of epidemiological studies

N Michels, C van Aart, J Morisse, A Mullee… - Critical Reviews in …, 2021 - Elsevier
This systematic review and meta-analysis provides epidemiological data on the relationship
between chronic inflammation, as measured by inflammatory blood parameters, and cancer …

The rise of gastrointestinal cancers as a global phenomenon: unhealthy behavior or progress?

SR Jardim, LMP de Souza, HSP de Souza - International journal of …, 2023 - mdpi.com
The overall burden of cancer is rapidly increasing worldwide, reflecting not only population
growth and aging, but also the prevalence and spread of risk factors. Gastrointestinal (GI) …

The exercise IL-6 enigma in cancer

ST Orange, J Leslie, M Ross, DA Mann… - Trends in Endocrinology …, 2023 - cell.com
Abstract Interleukin (IL)-6 elicits both anticancer and procancer effects depending on the
context, which we have termed the 'exercise IL-6 enigma'. IL-6 is released from skeletal …

Appropriate systemic therapy dosing for obese adult patients with cancer: ASCO guideline update

JJ Griggs, K Bohlke, EP Balaban, JJ Dignam… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE To provide recommendations for appropriate dosing of systemic antineoplastic
agents in obese adults with cancer. METHODS A systematic review of the literature collected …