Meningeal immunity and its function in maintenance of the central nervous system in health and disease

K Alves de Lima, J Rustenhoven… - Annual review of …, 2020 - annualreviews.org
Neuroimmunology, albeit a relatively established discipline, has recently sparked numerous
exciting findings on microglia, the resident macrophages of the central nervous system …

[HTML][HTML] The far-reaching scope of neuroinflammation after traumatic brain injury

DW Simon, MJ McGeachy, H Bayır, RSB Clark… - Nature Reviews …, 2017 - nature.com
The'silent epidemic'of traumatic brain injury (TBI) has been placed in the spotlight as a result
of clinical investigations and popular press coverage of athletes and veterans with single or …

[HTML][HTML] Neuroinflammation: microglia and T cells get ready to tango

STT Schetters, D Gomez-Nicola… - Frontiers in …, 2018 - frontiersin.org
In recent years, many paradigms concerning central nervous system (CNS) immunology
have been challenged and shifted, including the discovery of CNS-draining lymphatic …

[HTML][HTML] The role of the adaptive immune system and T cell dysfunction in neurodegenerative diseases

A DeMaio, S Mehrotra, K Sambamurti… - Journal of …, 2022 - Springer
The adaptive immune system and associated inflammation are vital in surveillance and host
protection against internal and external threats, but can secondarily damage host tissues …

[HTML][HTML] Breaking immune tolerance by targeting Foxp3+ regulatory T cells mitigates Alzheimer's disease pathology

K Baruch, N Rosenzweig, A Kertser… - Nature …, 2015 - nature.com
Alzheimer's disease (AD) is a neurodegenerative disorder in which chronic
neuroinflammation contributes to disease escalation. Nevertheless, while …

Multifaceted interactions between adaptive immunity and the central nervous system

J Kipnis - Science, 2016 - science.org
Neuroimmunologists seek to understand the interactions between the central nervous
system (CNS) and the immune system, both under homeostatic conditions and in diseases …

Secondary injury mechanisms in traumatic spinal cord injury: a nugget of this multiply cascade

C Oyinbo - Acta neurobiologiae experimentalis, 2011 - ane.pl
The pathophysiology of acute spinal cord injury (SCI) involves primary and secondary
mechanisms of injury. Though both mechanisms are involved in the neurological …

[HTML][HTML] Inflammation: a target for treatment in spinal cord injury

X Freyermuth-Trujillo, JJ Segura-Uribe… - Cells, 2022 - mdpi.com
Spinal cord injury (SCI) is a significant cause of disability, and treatment alternatives that
generate beneficial outcomes and have no side effects are urgently needed. SCI may be …

[HTML][HTML] Antibiotic-induced perturbations in microbial diversity during post-natal development alters amyloid pathology in an aged APPSWE/PS1ΔE9 murine model of …

MR Minter, R Hinterleitner, M Meisel, C Zhang… - Scientific reports, 2017 - nature.com
Recent evidence suggests the commensal microbiome regulates host immunity and
influences brain function; findings that have ramifications for neurodegenerative diseases. In …

[PDF][PDF] Dealing with danger in the CNS: the response of the immune system to injury

SP Gadani, JT Walsh, JR Lukens, J Kipnis - Neuron, 2015 - cell.com
Fighting pathogens and maintaining tissue homeostasis are prerequisites for survival. Both
of these functions are upheld by the immune system, though the latter is often overlooked in …