Down syndrome (DS) is the most common genetic disease and presents with cognitive
impairment, cardiac and gastrointestinal abnormalities, in addition to other miscellaneous …

Down syndrome is the most common chromosomal abnormality among live-born infants.
Through full or partial trisomy of chromosome 21, Down syndrome is associated with …

Purpose Rare genetic conditions like Down syndrome (DS) are historically understudied.
Infection is a leading cause of mortality in DS, along with cardiac anomalies. Currently, it is …

Down syndrome (DS) is typically caused by triplication of chromosome 21. Phenotypically,
DS presents with developmental, neurocognitive, and immune features. Epidemiologically …

Approximately 50% of newborns with Down syndrome have congenital heart disease. Non-
cardiac comorbidities may also be present. Many of the principles and strategies of …

Down syndrome (DS) is the most common chromosomal abnormality among live-born
infants. Respiratory tract infections are the most important cause of mortality in individuals …

Respiratory disease is a common cause of morbidity and mortality in children with Down's
syndrome (DS). Causes range from those problems common to many children with DS, such …

Children with Down syndrome have changes in their innate and adaptive immunity, which
contribute to increased rates of infections, autoimmune diseases, and haematological …

We present 4 pediatric patients with trisomy 21 (T21) and associated comorbidities who
developed coronavirus disease 2019 requiring hospitalization. A review of the literature …

Children with Down syndrome (DS) have wide range of respiratory problems. Although
underlying abnormalities in the respiratory system are important causes of morbidity and …