ERBB4 (HER4) is a member of the ERBB family of receptor tyrosine kinases, a family that
includes the epidermal growth factor receptor (EGFR/ERBB1/HER1), ERBB2 (Neu/HER2) …

Members of the ErbB subfamily of receptor tyrosine kinases are important regulators of
normal mammary gland physiology, and aberrations in their signaling have been associated …

ERBB4, one of four ErbB receptor tyrosine kinase family members, plays an important role in
the etiology and progression of lung cancer. In this study, we found that the ERBB4 protein …

ErbB4 isoforms mediate different cellular activities depending on their susceptibility to
proteolytic cleavage. The biological significance of ErbB4 cleavage in tumorigenesis …

Background Chronic inflammation is known to cause alterations in vascular homeostasis
that directly affects blood vessel morphogenesis, angiogenesis, and tissue permeability …

Diabetic microvascular complications, affecting the kidneys, retina, and the nervous system,
are a heavy burden for both the diabetic individual and society. The complications seem to …

Aim: Analysis of genes that play roles in multiple myeloma pathogenesis and their pathways
are current research topics. We aimed to detect expression of some genes in ErbB and …

Doxorubicin (dox) is one of the most potent chemotherapeutic drugs nowadays. However,
dox use in clinics is limited by its high myocardial toxicity. Recent evidence suggests that …

Doenças complexas são caracterizadas por serem poligênicas e multifatoriais, o que
representa um desafio em relação à busca de genes relacionados a elas. Com o advento …

The micro-and macrovascular long-term complications of diabetes account for the majority of
mortality and morbidity in diabetes. The diagnosis of diabetic nephropathy is highly …