Terminology, molecular features, epidemiology, and management of serrated colorectal neoplasia

SD Crockett, ID Nagtegaal - Gastroenterology, 2019 - Elsevier
In addition to the adenoma to carcinoma sequence, colorectal carcinogenesis can occur via
the serrated pathway. Studies have focused on clarification of categories and molecular …

Colorectal cancer: genetic abnormalities, tumor progression, tumor heterogeneity, clonal evolution and tumor-initiating cells

U Testa, E Pelosi, G Castelli - Medical Sciences, 2018 - mdpi.com
Colon cancer is the third most common cancer worldwide. Most colorectal cancer
occurrences are sporadic, not related to genetic predisposition or family history; however, 20 …

[HTML][HTML] An update on the morphology and molecular pathology of serrated colorectal polyps and associated carcinomas

RK Pai, M Bettington, A Srivastava, C Rosty - Modern Pathology, 2019 - Elsevier
Our understanding of serrated colorectal polyps has increased dramatically over the past
two decades and has led to a modern classification scheme for these lesions. Sessile …

Serrated colorectal lesions: an up-to-date review from histological pattern to molecular pathogenesis

M Mezzapesa, G Losurdo, F Celiberto, S Rizzi… - International Journal of …, 2022 - mdpi.com
Until 2010, colorectal serrated lesions were generally considered as harmless lesions and
reported as hyperplastic polyps (HPs) by pathologists and gastroenterologists. However …

The heterogeneous clinical and pathological landscapes of metastatic Braf-mutated colorectal cancer

GN Fanelli, CA Dal Pozzo, I Depetris, M Schirripa… - Cancer Cell …, 2020 - Springer
Colorectal cancer (CRC) is a complex and molecularly heterogeneous disease representing
one of the most frequent causes of cancer-related death worldwide. About 8–15% of CRCs …

Sessile serrated lesions with dysplasia: is it possible to nip them in the bud?

T Utsumi, Y Yamada, MT Diaz-Meco, J Moscat… - Journal of …, 2023 - Springer
The serrated neoplasia pathway constitutes an “alternative route” to colorectal cancer
(CRC), and sessile serrated lesions with dysplasia (SSLDs) are an intermediate step …

[HTML][HTML] Evolving pathologic concepts of serrated lesions of the colorectum

JH Kim, GH Kang - Journal of pathology and translational …, 2020 - synapse.koreamed.org
Here, we provide an up-to-date review of the histopathology and molecular pathology of
serrated colorectal lesions. First, we introduce the updated contents of the 2019 World …

[HTML][HTML] Standardized pathology report for colorectal cancer

B Kim, JM Kim, GH Kang, HJ Chang… - … of pathology and …, 2020 - synapse.koreamed.org
The first edition of the 'Standardized Pathology Report for Colorectal Cancer,'which was
developed by the Gastrointestinal Pathology Study Group (GIP) of the Korean Society of …

Current approaches in managing colonic serrated polyps and serrated polyposis

DE van Toledo, JEG IJspeert… - Annual review of …, 2022 - annualreviews.org
For decades, conventional adenomas were the only known precursor lesions of colorectal
cancer (CRC). Accordingly, education and research regarding CRC prevention were mainly …

Molecular diagnostics in colorectal carcinoma: advances and applications for 2018

A Bhalla, M Zulfiqar, MH Bluth - Clinics in laboratory …, 2018 - labmed.theclinics.com
The pathogenesis of colorectal carcinoma is heterogeneous and involves complex multistep
molecular pathways initiated by genetic and epigenetic events. The molecular classification …