The roles of androgens in humans: biology, metabolic regulation and health

M Alemany - International journal of molecular sciences, 2022 - mdpi.com
Androgens are an important and diverse group of steroid hormone molecular species. They
play varied functional roles, such as the control of metabolic energy fate and partition, the …

Hypogonadism and male obesity: focus on unresolved questions

M Grossmann - Clinical Endocrinology, 2018 - Wiley Online Library
Obesity, increasing in prevalence globally, is the clinical condition most strongly associated
with lowered testosterone concentrations in men and presents as one of the strongest …

[HTML][HTML] Effects of long-term testosterone treatment on cardiovascular outcomes in men with hypogonadism: rationale and design of the TRAVERSE study

S Bhasin, AM Lincoff, S Basaria, DC Bauer… - American Heart …, 2022 - Elsevier
Background Testosterone exerts some effects on the cardiovascular system that could be
considered beneficial; some other effects may potentially increase the risk of cardiovascular …

Aging and the male reproductive system

JM Kaufman, B Lapauw, A Mahmoud… - Endocrine …, 2019 - academic.oup.com
This narrative review presents an overview of current knowledge on fertility and reproductive
hormone changes in aging men, the factors driving and modulating these changes, their …

Obesity and male hypogonadism: Tales of a vicious cycle

DF Carrageta, PF Oliveira, MG Alves… - Obesity …, 2019 - Wiley Online Library
Obesity prevalence, particularly in children and young adults, is perilously increasing
worldwide foreseeing serious negative health impacts in the future to come. Obesity is linked …

Mechanisms underlying the metabolic actions of testosterone in humans: a narrative review

P Dandona, S Dhindsa, H Ghanim… - Diabetes, Obesity and …, 2021 - Wiley Online Library
The role of testosterone in improving sexual symptoms in men with hypogonadism is well
known. However, recent studies indicate that testosterone plays an important role in several …

Late‐onset hypogonadism: metabolic impact

M Grossmann, M Ng Tang Fui, AS Cheung - Andrology, 2020 - Wiley Online Library
Background Obesity and dysglycemia (comprising insulin resistance, the metabolic
syndrome and type 2 diabetes), that is diabesity, are associated with reduced circulating …

Metabolic changes in patients with prostate cancer during androgen deprivation therapy

K Mitsuzuka, Y Arai - International Journal of Urology, 2018 - Wiley Online Library
Androgen deprivation therapy continues to be widely used for the treatment of prostate
cancer despite the appearance of new‐generation androgen‐receptor targeting drugs after …

Metabolic syndrome and male fertility: beyond heart consequences of a complex cardiometabolic endocrinopathy

G Salvio, A Ciarloni, M Cutini, N Delli Muti… - International Journal of …, 2022 - mdpi.com
Metabolic syndrome (MetS) is a highly prevalent condition among adult males, affecting up
to 41% of men in Europe. It is characterized by the association of obesity, hypertension, and …

[HTML][HTML] Obesity, body composition, and sex hormones: implications for cardiovascular risk

P Singh, N Covassin, K Marlatt, KM Gadde… - Comprehensive …, 2021 - ncbi.nlm.nih.gov
Cardiovascular disease (CVD) continues to be the leading cause of death in adults,
highlighting the need to develop novel strategies to mitigate cardiovascular risk. The …