Abstract Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a
surprisingly large number of cellular processes and diseases. Several mechanisms play a …

The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its
complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from …

Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …

Abstract Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of
Alzheimer's disease (AD). GSK-3β is involved in the formation of paired helical filament …

NF-κB/Rel transcription factors control apoptosis, also known as programmed cell death.
This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing …

Drugs that cause liver injury often 'stress' mitochondria and activate signal transduction
pathways important in determining cell survival or death. In most cases, hepatocytes adapt …

Glycogen synthase kinase-3 (GSK-3) has attracted much scrutiny due to its plethora of
cellular functions, novel mechanisms of regulation and its potential as a therapeutic target …

β-Amyloid (Aβ) plaques in Alzheimer (AD) brains are surrounded by severe dendritic and
axonal changes, including local spine loss, axonal swellings and distorted neurite …

Glycogen synthase kinase (GSK)-3β is a constitutively active, proline-directed
serine/threonine kinase that controls growth modulation and tumorigenesis through multiple …

Radiotherapy is one of the major treatment regimes for thoracic malignancies, but can lead
to severe lung complications including pneumonitis and fibrosis. Recent studies suggest that …