The glamour and gloom of glycogen synthase kinase-3
RS Jope, GVW Johnson - Trends in biochemical sciences, 2004 - cell.com
Abstract Glycogen synthase kinase-3 (GSK3) is now recognized as a key component of a
surprisingly large number of cellular processes and diseases. Several mechanisms play a …
surprisingly large number of cellular processes and diseases. Several mechanisms play a …
Lithium and GSK-3: one inhibitor, two inhibitory actions, multiple outcomes
RS Jope - Trends in pharmacological sciences, 2003 - cell.com
The intrigue of lithium, the simplest drug in the modern pharmacopoeia, extends from its
complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from …
complex actions in cells to its therapeutic effects as a mood stabilizer. New surprises from …
Glycogen synthase kinase-3 (GSK3) in psychiatric diseases and therapeutic interventions
RS Jope, MS Roh - Current drug targets, 2006 - ingentaconnect.com
Glycogen synthase kinase-3 (GSK3) has recently been linked to mood disorders and
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …
schizophrenia, and the neurotransmitter systems and therapeutic treatments associated with …
GSK-3 is essential in the pathogenesis of Alzheimer's disease
A Takashima - Journal of Alzheimer's disease, 2006 - content.iospress.com
Abstract Glycogen synthase kinase-3 (GSK-3) is a pivotal molecule in the development of
Alzheimer's disease (AD). GSK-3β is involved in the formation of paired helical filament …
Alzheimer's disease (AD). GSK-3β is involved in the formation of paired helical filament …
Gadd45β mediates the NF-κB suppression of JNK signalling by targeting MKK7/JNKK2
NF-κB/Rel transcription factors control apoptosis, also known as programmed cell death.
This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing …
This control is crucial for oncogenesis, cancer chemo-resistance and for antagonizing …
[HTML][HTML] Regulation of drug-induced liver injury by signal transduction pathways: critical role of mitochondria
D Han, L Dara, S Win, TA Than, L Yuan… - Trends in …, 2013 - cell.com
Drugs that cause liver injury often 'stress' mitochondria and activate signal transduction
pathways important in determining cell survival or death. In most cases, hepatocytes adapt …
pathways important in determining cell survival or death. In most cases, hepatocytes adapt …
Glycogen synthase kinase-3-an overview of an over-achieving protein kinase
L Kockeritz, B Doble, S Patel… - Current drug targets, 2006 - ingentaconnect.com
Glycogen synthase kinase-3 (GSK-3) has attracted much scrutiny due to its plethora of
cellular functions, novel mechanisms of regulation and its potential as a therapeutic target …
cellular functions, novel mechanisms of regulation and its potential as a therapeutic target …
Activation of glycogen synthase kinase-3 beta mediates β-amyloid induced neuritic damage in Alzheimer's disease
B DaRocha-Souto, M Coma, BG Perez-Nievas… - Neurobiology of …, 2012 - Elsevier
β-Amyloid (Aβ) plaques in Alzheimer (AD) brains are surrounded by severe dendritic and
axonal changes, including local spine loss, axonal swellings and distorted neurite …
axonal changes, including local spine loss, axonal swellings and distorted neurite …
[HTML][HTML] Genetic deletion of glycogen synthase kinase-3β abrogates activation of IκBα kinase, JNK, Akt, and p44/p42 MAPK but potentiates apoptosis induced by …
Y Takada, X Fang, MS Jamaluddin, DD Boyd… - Journal of Biological …, 2004 - ASBMB
Glycogen synthase kinase (GSK)-3β is a constitutively active, proline-directed
serine/threonine kinase that controls growth modulation and tumorigenesis through multiple …
serine/threonine kinase that controls growth modulation and tumorigenesis through multiple …
ERK/GSK3β/Snail signaling mediates radiation-induced alveolar epithelial-to-mesenchymal transition
D Nagarajan, T Melo, Z Deng, C Almeida… - Free Radical Biology and …, 2012 - Elsevier
Radiotherapy is one of the major treatment regimes for thoracic malignancies, but can lead
to severe lung complications including pneumonitis and fibrosis. Recent studies suggest that …
to severe lung complications including pneumonitis and fibrosis. Recent studies suggest that …