Thioacetamide (TAA) undergoes bioactivation in the liver by the CYP450 2E1 enzyme,
resulting in the formation of TAA-S-oxide and TAA-S-dioxide. TAA-S-dioxide induces …

Long-term liver injuries lead to hepatic fibrosis, often progressing into cirrhosis, liver failure,
portal hypertension, and hepatocellular carcinoma. There is currently no effective therapy …

Hepatic fibrosis causes severe morbidity and death. No viable treatment can repair fibrosis
and protect the liver until now. We intended to discover the empagliflozin's (EMPA) …

The kidney flushes out toxic substances and metabolic waste products, and homeostasis is
maintained owing to the kidney efforts. Unfortunately, kidney disease is one of the illnesses …

In the present study, we aimed to delineate the neuroprotective potential of thymol (THY)
against neurotoxicity and cognitive deterioration induced by thioacetamide (TAA) in an …

Erythropoietin (EPO) is recognized for its function in erythropoiesis; however, its potential
antifibrotic effect against liver fibrosis remains unknown. This study examined whether EPO …

Liver fibrosis is one of the leading causes of hepatic sclerosis and hepatocellular carcinoma
worldwide. However, the complex pathophysiological mechanisms of liver fibrosis are …

Aim Liver cirrhosis is the result of a vicious cycle of both chronic oxidative stress and
inflammation. NADPH oxidase-4 (NOX4) and its companion, NOD-like receptor protein 3 …

Simple Summary Liver fibrosis is a challenging global health problem resulting in a
significant morbidity and mortality rates worldwide due to its rapid progression to cirrhosis …

Background Several hepatotoxicants such as acetaminophen, carbon tetrachloride, and
thioacetamide are repeatedly used to develop hepatic fibrosis to mimic the histological and …