To cope with DNA damage, cells possess a complex signaling network called the 'DNA
damage response', which coordinates cell cycle control with DNA repair. The importance of …

The long non-coding RNA, plasmacytoma variant translocation 1 (PVT1), is highly
expressed in a variety of tumors, and is believed to be a potential oncogene. However, the …

Cancer risk at low doses of ionizing radiation remains poorly defined because of ambiguity
in the quantitative link to doses below 0.2 Sv in atomic bomb survivors in Hiroshima and …

Ataxia-telangiectasia mutated (ATM) is needed for the initiation of the double-strand break
(DSB) repair by homologous recombination (HR). ATM triggers DSB end resection by …

The CHD1 gene, encoding the chromo‐domain helicase DNA‐binding protein‐1, is one of
the most frequently deleted genes in prostate cancer. Here, we examined the role of CHD1 …

The PI3K/Akt/mTOR pathway is frequently altered in human papillomavirus (HPV)-positive
and negative squamous cell carcinoma of the head and neck (HNSCC) and overstimulation …

PARP inhibitors have been approved for treatment of tumors with mutations in or loss of
BRCA1/2. The molecular mechanisms and particularly the cellular phenotypes resulting in …

BACKGROUND: Cellular and clinical sensitivity to ionizing radiation (IR) is determined by
DNA double-strand breaks (DSB) repair. Here, we investigate the molecular mechanism …

ATM is a key mediator of radiation response, and pharmacological inhibition of ATM is a
rational strategy to radiosensitize tumors. AZD1390 is a brain-penetrant ATM inhibitor and a …

High expression of Aurora kinase A (Aurora-A) has been found to confer cancer cell radio-
and chemoresistance, however, the underlying mechanism is unclear. In this study, by using …