Writing, erasing and reading histone lysine methylations
K Hyun, J Jeon, K Park, J Kim - Experimental & molecular medicine, 2017 - nature.com
Histone modifications are key epigenetic regulatory features that have important roles in
many cellular events. Lysine methylations mark various sites on the tail and globular …
many cellular events. Lysine methylations mark various sites on the tail and globular …
Chemoenzymatic semisynthesis of proteins
RE Thompson, TW Muir - Chemical reviews, 2019 - ACS Publications
Protein semisynthesis—defined herein as the assembly of a protein from a combination of
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …
synthetic and recombinant fragments—is a burgeoning field of chemical biology that has …
Mechanism of cross-talk between H2B ubiquitination and H3 methylation by Dot1L
Methylation of histone H3 K79 by Dot1L is a hallmark of actively transcribed genes that
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
depends on monoubiquitination of H2B K120 (H2B-Ub) and is an example of histone …
Structural basis of Dot1L stimulation by histone H2B lysine 120 ubiquitination
MI Valencia-Sánchez, P De Ioannes, M Wang… - Molecular cell, 2019 - cell.com
The essential histone H3 lysine 79 methyltransferase Dot1L regulates transcription and
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …
genomic stability and is deregulated in leukemia. The activity of Dot1L is stimulated by mono …
Structural basis for recognition of ubiquitylated nucleosome by Dot1L methyltransferase
CJ Anderson, MR Baird, A Hsu, EH Barbour, Y Koyama… - Cell reports, 2019 - cell.com
Summary Histone H3 lysine 79 (H3K79) methylation is enriched on actively transcribed
genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides …
genes, and its misregulation is a hallmark of leukemia. Methylation of H3K79, which resides …
Structural basis of H2B ubiquitination-dependent H3K4 methylation by COMPASS
The COMPASS (complex of proteins associated with Set1) complex represents the prototype
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
of the SET1/MLL family of methyltransferases that controls gene transcription by H3K4 …
Interrogating epigenetic mechanisms with chemically customized chromatin
Genetic and genomic techniques have proven incredibly powerful for identifying and
studying molecular players implicated in the epigenetic regulation of DNA-templated …
studying molecular players implicated in the epigenetic regulation of DNA-templated …
Nature-inspired protein ligation and its applications
The ability to manipulate the chemical composition of proteins and peptides has been
central to the development of improved polypeptide-based therapeutics and has enabled …
central to the development of improved polypeptide-based therapeutics and has enabled …
Structural basis for COMPASS recognition of an H2B-ubiquitinated nucleosome
EJ Worden, X Zhang, C Wolberger - Elife, 2020 - elifesciences.org
Methylation of histone H3K4 is a hallmark of actively transcribed genes that depends on
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
mono-ubiquitination of histone H2B (H2B-Ub). H3K4 methylation in yeast is catalyzed by …
A promiscuous split intein with expanded protein engineering applications
The protein trans-splicing (PTS) activity of naturally split inteins has found widespread use in
chemical biology and biotechnology. However, currently used naturally split inteins suffer …
chemical biology and biotechnology. However, currently used naturally split inteins suffer …