Pertussis is a severe respiratory infection caused by Bordetella pertussis, and in 2008,
pertussis was associated with an estimated 16 million cases and 195,000 deaths globally …

Pertussis is an acute respiratory disease caused by Bordetella pertussis. Due to its
frequency and severity, prevention of pertussis has been considered an important public …

Estimating the rates at which bacterial genomes evolve is critical to understanding major
evolutionary and ecological processes such as disease emergence, long-term host …

Abstract Group A Streptococcus (GAS; Streptococcus pyogenes) is a bacterial pathogen for
which a commercial vaccine for humans is not available. Employing the advantages of high …

Background The recent increase in whooping cough incidence (primarily caused by
Bordetella pertussis) presents a challenge to both public health practitioners and scientists …

There is a growing appreciation for the role of vaccines in confronting the problem of
antimicrobial resistance (AMR). Vaccines can reduce the prevalence of resistance by …

The discovery of vaccine antigens through whole genome sequencing (WGS) contrasts with
the classical hypothesis-driven laboratory-based analysis of microbes to identify …

Phylogenetic methods can use the sampling times of molecular sequence data to calibrate
the molecular clock, enabling the estimation of evolutionary rates and timescales for rapidly …

The timelines for developing vaccines against infectious diseases are lengthy, and often
vaccines that reach the stage of large phase 3 field trials fail to provide the desired level of …

As with other pathogens, competitive interactions between Bordetella pertussis strains drive
infection risk. Vaccines are thought to perturb strain diversity through shifts in immune …