This article reviews the involvement of the mitochondrial permeability transition pore in
necrotic and apoptotic cell death. The pore is formed from a complex of the voltage …

Zinc is an important trace element in biology. An important pool of zinc in the brain is the one
present in synaptic vesicles in a subgroup of glutamatergic neurons. In this form it can be …

Hypothermia has been proposed as a neuroprotective strategy. However, short-term cooling
after hypoxia-ischemia is effective only if started immediately during resuscitation. The aim of …

In the human brain and spinal cord, neurons degenerate after acute insults (eg, stroke,
cardiac arrest, trauma) and during progressive, adult-onset diseases [eg, amyotrophic lateral …

Acute post-asphyxial encephalopathy occurring around the time of birth remains a major
cause of death and disability. The recent seminal insight that allows active neuroprotective …

Hypoxic ischemia is a common cause of damage to the fetal and neonatal brain. Although
systemic and cerebrovascular physiologic factors play an important role in the initial phases …

A range of molecules control nerve-cell survival in the brain. Many of these molecules might
be neuroprotective through activation of the transcription factor cAMP-response-element …

Acute hypoxic–ischemic encephalopathy around the time of birth remains a major cause of
death and life-long disability. The key insight that led to the modern revival of studies of …

Forty years of research into the function of l-glutamic acid as a neurotransmitter in the
vertebrate central nervous system (CNS) have uncovered a tremendous complexity in the …

General anesthetics are commonly used in major surgery. To achieve the depth of
anesthesia for surgery, patients are being subjected to a variety of general anesthetics …