Several methods of treatment are available to patients with melasma. First-line therapy
usually consists of topical compounds that affect the pigment production pathway, broad …

Melasma is a commonly acquired hypermelanosis that affects sun-exposed areas of the
skin, with frequent facial involvement. Its histologic manifestations are evident in the …

Identifying genomic locations that have experienced selective sweeps is an important first
step toward understanding the molecular basis of adaptive evolution. Using statistical …

Recently melanogenic paracrine or autocrine cytokine networks have been discovered in
vitro between melanocytes and other types of skin cells. These include endothelin (ET)‐1 …

Vitiligo is the most common acquired pigmentary disorder, which afflicts 0.5%–1% of the
world population, and is characterized by depigmented skin patches resulting from …

Dramatic pigmentation changes have evolved within most vertebrate groups, including fish
and humans. Here we use genetic crosses in sticklebacks to investigate the parallel origin of …

Vitiligo is a skin disease that is caused by selective destruction of melanocytes and is
characterized by white spots. Melanocytes and keratinocytes seem to exhibit a functional …

Abstract Ultraviolet-light (UV)-induced tanning is defective in numerous 'fair-
skinned'individuals, many of whom contain functional disruption of the melanocortin 1 …

Malignant melanoma is a chemotherapy‐resistant cancer with high mortality. Recent
advances in our understanding of the disease at the molecular level have indicated that it …

Hair color differences are among the most obvious examples of phenotypic variation in
humans. Although genome-wide association studies (GWAS) have implicated multiple loci …