Mechanisms of oxidative stress in metabolic syndrome

SK Masenga, LS Kabwe, M Chakulya… - International journal of …, 2023 - mdpi.com
Metabolic syndrome is a cluster of conditions associated with the risk of diabetes mellitus
type 2 and cardiovascular diseases (CVDs). Metabolic syndrome is closely related to …

Bioelectronic medicine: preclinical insights and clinical advances

VA Pavlov, KJ Tracey - Neuron, 2022 - cell.com
The nervous system maintains homeostasis and health. Homeostatic disruptions underlying
the pathobiology of many diseases can be controlled by bioelectronic devices targeting CNS …

Integrated approach to reducing polypharmacy in older people: exploring the role of oxidative stress and antioxidant potential therapy

C Rojas-Solé, V Pinilla-González, J Lillo-Moya… - Redox …, 2024 - Taylor & Francis
Increased life expectancy, attributed to improved access to healthcare and drug
development, has led to an increase in multimorbidity, a key contributor to polypharmacy …

Attapulgite doped with Fe and Cu nanooxides as peroxidase nanozymes for antibacterial coatings

F Feng, X Zhang, B Mu, P Wang, Z Chen… - ACS Applied Nano …, 2022 - ACS Publications
The search for low-cost, highly efficient, and stable nanozymes mimicking peroxidase (POD)
enzymes remains a great challenge in the development of valuable antibacterial …

Peripheral and central macrophages in obesity

S Mukherjee, S Skrede, M Haugstøyl… - Frontiers in …, 2023 - frontiersin.org
Obesity is associated with chronic, low-grade inflammation. Excessive nutrient intake causes
adipose tissue expansion, which may in turn cause cellular stress that triggers infiltration of …

[HTML][HTML] Neuroimmune nexus in the pathophysiology and therapy of inflammatory disorders: Role of α7 nicotinic acetylcholine receptors

KR Keever, VP Yakubenko, DB Hoover - Pharmacological Research, 2023 - Elsevier
The α7-nicotinic acetylcholine receptor (α7nAChR) is a key protein in the cholinergic anti-
inflammatory pathway (CAP) that links the nervous and immune systems. Initially, the …

Effect of cholinesterase inhibitors on mortality in patients with dementia: a systematic review of randomized and nonrandomized trials

C Truong, C Recto, C Lafont, F Canoui-Poitrine… - Neurology, 2022 - AAN Enterprises
Background and Objectives Cholinesterase inhibitors (ChEIs) have cardiovascular effects in
addition to their neurologic activity and might alter mortality. We wanted to know whether …

Oxidative Stress Biomarkers and Mitochondrial DNA Copy Number Associated with APOE4 Allele and Cholinesterase Inhibitor Therapy in Patients with Alzheimer's …

CW Liou, SH Chen, TK Lin, MH Tsai, CC Chang - Antioxidants, 2021 - mdpi.com
Studies of the oxidative/anti-oxidative status in patients with Alzheimer's disease (AD)
carrying different alleles of the apolipoprotein E (APOE) gene are currently inconclusive; …

[HTML][HTML] Association between cholinesterase inhibitors and kidney function decline in patients with Alzheimer's dementia

H Xu, S Garcia-Ptacek, A Bruchfeld, EL Fu, TD Shori… - Kidney International, 2023 - Elsevier
Preclinical evidence shows that activation of the cholinergic anti-inflammatory pathway
(CAP) may have direct and indirect beneficial effects on the kidney. Cholinesterase …

The cholinergic drug pyridostigmine alleviates inflammation during LPS-induced acute respiratory distress syndrome

PN Bricher Choque, RP Vieira, L Ulloa… - Frontiers in …, 2021 - frontiersin.org
Acute respiratory distress syndrome (ARDS) is a critical illness complication that is
associated with high mortality. ARDS is documented in severe cases of COVID-19. No …