Determining the toxicity of chemicals is necessary to identify their harmful effects on humans,
animals, plants, or the environment. It is also one of the main steps in drug design. Animal …

The Hill equation was first introduced by AV Hill to describe the equilibrium relationship
between oxygen tension and the saturation of haemoglobin. In pharmacology, the Hill …

Summary The CDK4/6 inhibitor, palbociclib (PAL), significantly improves progression-free
survival in HR+/HER2− breast cancer when combined with anti-hormonals. We sought to …

We report the preclinical evaluation of PF-06463922, a potent and brain-penetrant
ALK/ROS1 inhibitor. Compared with other clinically available ALK inhibitors, PF-06463922 …

This review addresses the 100-year-old Hill equation (published in January 22, 1910), the
first formula relating the result of a reversible association (eg, concentration of a complex …

Glucocorticoids have pleiotropic effects that are used to treat diverse diseases such as
asthma, rheumatoid arthritis, systemic lupus erythematosus and acute kidney transplant …

The focus of this book is primarily on the development of pharmacokinetic and
pharmacokinetic-pharmacodynamic models. Models that are reported in the literature are …

Pharmacokinetic-pharmacodynamic (PKPD) modeling and simulation has evolved as an
important tool for rational drug development and drug use, where developed models …

Drug discovery is often impeded by the poor predictability of in vitro assays for drug toxicity.
One primary reason for this observation is the inability to reproduce the pharmacokinetics …

Oncogenic c-ros oncogene1 (ROS1) fusion kinases have been identified in a variety of
human cancers and are attractive targets for cancer therapy. The MET/ALK/ROS1 inhibitor …