A molecular motor is made of either a single macromolecule or a macromolecular complex.
Just like their macroscopic counterparts, molecular motors “transduce” input energy into …

Optimization aims to make a system or design as effective or functional as possible.
Mathematical optimization methods are widely used in engineering, economics and science …

Background We consider the problem of parameter estimation (model calibration) in
nonlinear dynamic models of biological systems. Due to the frequent ill-conditioning and …

Inferring knowledge about biological processes by a mathematical description is a major
characteristic of Systems Biology. To understand and predict system's behavior the available …

The transcription factor FoxO1 contributes to the metabolic adaptation to fasting by
suppressing muscle oxidation of glucose, sparing it for glucose-dependent tissues …

Time dynamics are often ignored in causal modelling. Clearly, causality must operate in time
and we show how this corresponds to a mechanistic, or system, understanding of causality …

Tissue engineering is a radically different approach to reconstruction of the body following
degenerative diseases, trauma or chronic debilitating conditions. Although there have been …

A natural product betulinic acid (BA) has gained a huge significance in the recent years for
its strong cytotoxicity. Surprisingly, in spite of being an interesting cancer protecting agent on …

Human body weight (BW), or some variable related to it, is physiologically regulated. That is,
negative feedback from changes in BW elicits compensatory influences on appetite, which …

The simecol package provides an open structure to implement, simulate and share
ecological models. A generalized object-oriented architecture improves readability and …