Akkermansia muciniphila: paradigm for next-generation beneficial microorganisms

PD Cani, C Depommier, M Derrien, A Everard… - Nature Reviews …, 2022 - nature.com
Ever since Akkermansia muciniphila was discovered and characterized two decades ago,
numerous studies have shown that the lack or decreased abundance of this commensal …

[HTML][HTML] Microbial regulation of host physiology by short-chain fatty acids

B van der Hee, JM Wells - Trends in Microbiology, 2021 - cell.com
Our ancestral diet consisted of much more nondigestible fiber than that of many societies
today. Thus, from an evolutionary perspective the human genome and its physiological and …

A non-antibiotic-disrupted gut microbiome is associated with clinical responses to CD19-CAR-T cell cancer immunotherapy

CK Stein-Thoeringer, NY Saini, E Zamir… - Nature medicine, 2023 - nature.com
Increasing evidence suggests that the gut microbiome may modulate the efficacy of cancer
immunotherapy. In a B cell lymphoma patient cohort from five centers in Germany and the …

[HTML][HTML] Shaping the future of probiotics and prebiotics

M Cunningham, MA Azcarate-Peril, A Barnard… - Trends in …, 2021 - cell.com
Recent and ongoing developments in microbiome science are enabling new frontiers of
research for probiotics and prebiotics. Novel types, mechanisms, and applications currently …

[HTML][HTML] Impact of bacterial metabolites on gut barrier function and host immunity: a focus on bacterial metabolism and its relevance for intestinal inflammation

N Gasaly, P De Vos, MA Hermoso - Frontiers in immunology, 2021 - frontiersin.org
The diverse and dynamic microbial community of the human gastrointestinal tract plays a
vital role in health, with gut microbiota supporting the development and function of the gut …

[HTML][HTML] High-fat, western-style diet, systemic inflammation, and gut microbiota: a narrative review

IJ Malesza, M Malesza, J Walkowiak, N Mussin… - Cells, 2021 - mdpi.com
The gut microbiota is responsible for recovering energy from food, providing hosts with
vitamins, and providing a barrier function against exogenous pathogens. In addition, it is …

[HTML][HTML] Imbalanced gut microbiota fuels hepatocellular carcinoma development by shaping the hepatic inflammatory microenvironment

KM Schneider, A Mohs, W Gui, EJC Galvez… - Nature …, 2022 - nature.com
Hepatocellular carcinoma (HCC) is a leading cause of cancer-related deaths worldwide,
and therapeutic options for advanced HCC are limited. Here, we observe that intestinal …

[HTML][HTML] The role of microbiota in infant health: from early life to adulthood

Y Yao, X Cai, Y Ye, F Wang, F Chen… - Frontiers in …, 2021 - frontiersin.org
From early life to adulthood, the microbiota play a crucial role in the health of the infant. The
microbiota in early life are not only a key regulator of infant health but also associated with …

[HTML][HTML] Short chain fatty acids (SCFAs)-mediated gut epithelial and immune regulation and its relevance for inflammatory bowel diseases

D Parada Venegas, MK De la Fuente… - Frontiers in …, 2019 - frontiersin.org
Ulcerative colitis (UC) and Crohn's disease (CD), collectively known as Inflammatory Bowel
Diseases (IBD), are caused by a complex interplay between genetic, immunologic, microbial …

[HTML][HTML] What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases

E Rinninella, P Raoul, M Cintoni, F Franceschi… - Microorganisms, 2019 - mdpi.com
Each individual is provided with a unique gut microbiota profile that plays many specific
functions in host nutrient metabolism, maintenance of structural integrity of the gut mucosal …