Acute kidney injury (AKI) has been reported in up to 25% of critically-ill patients with SARS-
CoV-2 infection, especially in those with underlying comorbidities. AKI is associated with …

An explosion in single-cell technologies has revealed a previously underappreciated
heterogeneity of cell types and novel cell-state associations with sex, disease, development …

Recent studies have emphasized the importance of single-cell spatial biology, yet available
assays for spatial transcriptomics have limited gene recovery or low spatial resolution. Here …

Understanding kidney disease relies on defining the complexity of cell types and states, their
associated molecular profiles and interactions within tissue neighbourhoods. Here we …

Spatial transcriptomic and proteomic technologies have provided new opportunities to
investigate cells in their native microenvironment. Here we present Giotto, a comprehensive …

Isotope tracing has helped to determine the metabolic activities of organs. Methods to probe
metabolic heterogeneity within organs are less developed. We couple stable-isotope …

Acute kidney injury (AKI), commonly caused by ischemia, sepsis, or nephrotoxic insult, is
associated with increased mortality and a heightened risk of chronic kidney disease (CKD) …

Single-cell RNA sequencing methods can profile the transcriptomes of single cells but
cannot preserve spatial information. Conversely, spatial transcriptomics assays can profile …

Determining the epigenetic program that generates unique cell types in the kidney is critical
for understanding cell-type heterogeneity during tissue homeostasis and injury response …

Self-renewal and differentiation are tightly controlled to maintain haematopoietic stem cell
(HSC) homeostasis in the adult bone marrow,. During fetal development, expansion of …