Intercellular communication is a key feature of cancer progression and metastasis.
Extracellular vesicles (EVs) are generated by all cells, including cancer cells, and recent …

Melanoma is the most lethal skin cancer that originates from the malignant transformation of
melanocytes. Although melanoma has long been regarded as a cancerous malignancy with …

To flourish, cancers greatly depend on their surrounding tumor microenvironment (TME),
and cancer-associated fibroblasts (CAFs) in TME are critical for cancer occurrence and …

Despite centuries since the discovery and study of cancer, cancer is still a lethal and
intractable health issue worldwide. Cancer-associated fibroblasts (CAFs) have gained much …

As a critical component of the tumor microenvironment (TME), cancer‐associated fibroblasts
(CAFs) play important roles in cancer initiation and progression. Well‐known signaling …

The communication between tumor-derived elements and stroma in the metastatic niche has
a critical role in facilitating cancer metastasis. Yet, the mechanisms tumor cells use to control …

Background Hepatocellular carcinoma (HCC) remains a global challenge due to its high
morbidity and mortality rates as well as poor response to treatment. The communication …

The changes associated with malignancy are not only in cancer cells but also in
environment in which cancer cells live. Metabolic reprogramming supports tumor cell high …

Extracellular vesicles (EVs), a class of heterogeneous membrane vesicles, are generally
divided into exosomes and microvesicles on basis of their origination from the endosomal …

Purpose The present review aimed to assess the role of exosomal miRNAs in cancer-
associated fibroblasts (CAFs), normal fibroblasts (NFs), and cancer cells. The roles of …