Background Animal studies and trials in older children and adults suggest that a'one dose
per day'regimen of gentamicin is superior to a'multiple doses per day'regimen. Objectives To …

Aminoglycosides constitute one of the oldest classes of antimicrobials. Despite their toxicity,
mainly nephrotoxicity and ototoxicity, aminoglycosides are valuable in current clinical …

Gentamicin is commonly used in the management of neonatal infections. Development of
adaptive resistance is typical for aminoglycosides and reduces the antibacterial effect. There …

Objectives In the heterogeneous group of preterm and term neonates, gentamicin and
tobramycin are mainly dosed according to empirical guidelines, after which therapeutic drug …

Background: Aminoglycoside-induced ototoxicity has been reported in neonates but its
incidence is poorly defined, whereas vancomycin-induced ototoxicity has not been reported …

Dosing regimens often recommend lower gentamicin doses in neonates (3–5 mg/kg) than in
older children (7 mg/kg or more) despite the higher volume of distribution in neonates. We …

Understanding pharmacokinetics/pharmacodynamics in managing... : Current Opinion in
Infectious Diseases Understanding pharmacokinetics/pharmacodynamics in managing …

Gentamicin is a bactericidal aminoglycoside antibiotic, it inhibits the protein synthesis.
Gentamicin is active against the majority of aerobic gram-negative bacilli such as …

Objective To investigate gentamicin pharmacokinetics in neonates with moderate-to-severe
hypoxic-ischemic encephalopathy (HIE) who underwent therapeutic hypothermia (TH) …

OBJECTIVE: To evaluate the usefulness of extended-interval gentamicin dosing practiced in
neonatal intensive care unit (NICU) and special care nursery (SCN) of a Malaysian hospital …