[HTML][HTML] Dissecting the crosstalk between Nrf2 and NF-κB response pathways in drug-induced toxicity
W Gao, L Guo, Y Yang, Y Wang, S Xia… - Frontiers in cell and …, 2022 - frontiersin.org
Nrf2 and NF-κB are important regulators of the response to oxidative stress and
inflammation in the body. Previous pharmacological and genetic studies have confirmed …
inflammation in the body. Previous pharmacological and genetic studies have confirmed …
Histopathological evaluation of contrast‐induced acute kidney injury rodent models
Contrast‐induced acute kidney injury (CI‐AKI) can occur in 3–25% of patients receiving
radiocontrast material (RCM) despite appropriate preventive measures. Often patients with …
radiocontrast material (RCM) despite appropriate preventive measures. Often patients with …
A novel effect of Aprepitant: Protection for cisplatin-induced nephrotoxicity and hepatotoxicity
Cisplatin is widely used chemotherapeutic drug and have some serious side effects as
tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug …
tissue toxicity and nausea and vomiting. Aprepitant is used in clinic as an anti-emetic drug …
[HTML][HTML] The protective roles of butein on indomethacin induced gastric ulcer in mice
Objective Butein is a potential agent first isolated from Rhus verniciflua that has medicinal
value in East Asia and has been used in the treatment of gastritis, gastric cancer, and …
value in East Asia and has been used in the treatment of gastritis, gastric cancer, and …
Infliximab abrogates cadmium-induced testicular damage and spermiotoxicity via enhancement of steroidogenesis and suppression of inflammation and apoptosis …
Cadmium (Cd) is a serious environmental and occupational contaminant that represents a
serious health hazard to humans and other animals. Reproductive health problems have …
serious health hazard to humans and other animals. Reproductive health problems have …
[HTML][HTML] The potential biotherapeutic targets of contrast-induced acute kidney injury
AS Cheng, X Li - International journal of molecular sciences, 2023 - mdpi.com
Contrast-induced acute kidney injury (CI− AKI) is manifested by an abrupt decline in kidney
function as a consequence of intravascular exposure to contrast media. With the increased …
function as a consequence of intravascular exposure to contrast media. With the increased …
The role of urotensin-II and its receptors in sepsis-induced lung injury under diabetic conditions
This study aimed to investigate the potential role of urotensin-II receptors in sepsis-induced
lung injury in diabetic mice using urotensin-II receptor agonists and antagonists. A total of …
lung injury in diabetic mice using urotensin-II receptor agonists and antagonists. A total of …
Inactivation of Wnt/β-catenin/renin angiotensin axis by tumor necrosis factor-alpha inhibitor, infliximab, ameliorates CKD induced in rats
Infliximab (IFX), a chimeric monoclonal antibody against tumor necrosis factor-α (TNF-α), is
widely used to treat autoimmune diseases and chronic diseases associated with …
widely used to treat autoimmune diseases and chronic diseases associated with …
TNF or EGFR inhibition equally block AKI-to-CKD transition: opportunities for etanercept treatment
MM Abdelmageed, E Kefaloyianni… - Nephrology Dialysis …, 2023 - academic.oup.com
Background Inflammation is a key driver of the transition of acute kidney injury to
progressive fibrosis and chronic kidney disease (AKI-to-CKD transition). Blocking a …
progressive fibrosis and chronic kidney disease (AKI-to-CKD transition). Blocking a …
Aprepitant: an antiemetic drug, contributes to the prevention of acute lung injury with its anti-inflammatory and antioxidant properties
Objectives We investigated, the effects of aprepitant (APRE) on the lung tissues of rats with
an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) …
an experimental polymicrobial sepsis model (CLP: cecal ligation and puncture) …