The production of active pharmaceutical ingredients (APIs) is currently undergoing its
biggest transformation in a century. The changes are based on the rapid and dramatic …

Cell culture media (CCM) used in industrial biotechnology are complex mixtures of
molecules and elements that are inherently difficult to analyze comprehensively. CCM …

Disclosed herein are compositions and methods for purifying antibody products from a
sample matrix. In particular, the present invention relates to compositions and methods for …

Soy hydrolysates are widely used as a nutrient supplement in mammalian cell culture for the
production of recombinant proteins. The batch‐to‐batch variability of a soy hydrolysate often …

The instant invention relates to the field of protein production and purification, and in
particular to compositions and processes for controlling the distribution or amount of lysine …

The instant invention relates to the field of protein production and purification, and in
particular to compositions and processes for controlling the amount of charge variants …

For many decades bovine serum has been used as an essential component for the growth
of animal cells in culture. However, the combined disadvantages of variability in …

The instant invention relates to the field of protein production and purification, and in
particular to compositions and processes for controlling the amount of acidic species …

The present invention is directed to methods for purifying a protein of interest, eg, an
antibody, from a sample compris ing the protein of interest and at least one impurity, eg, an …

4,933.435 A 6/1990 Ngo 7,070,775 B2 7/2006 Le et al. 4,968,615. A 1 1/1990 Koszinowski
et al. 7,084.260 B1 8/2006 Lonberg et al. 5,045,468 A 9, 1991 Darfler 7,122,641 B2 10/2006 …