Cancer arises in the context of an in vivo tumor microenvironment. This microenvironment is
both a cause and consequence of tumorigenesis. Tumor and host cells co-evolve …

Vascular endothelial growth factor (VEGF) is a key regulator of physiological angiogenesis
during embryogenesis, skeletal growth and reproductive functions. VEGF has also been …

Mononuclear phagocytes are versatile cells that can express different functional programs in
response to microenvironmental signals. Fully polarized M1 and M2 (or alternatively …

It has become evident that we cannot understand tumour growth without considering
components of the stromal microenvironment, such as the vasculature. At the same time, the …

Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen in vitro and
an angiogenic inducer in a variety of in vivo models. Hypoxia has been shown to be a major …

Tumour-associated macrophages (TAM) represent the major inflammatory component of the
stroma of many tumours, and can affect different aspects of the neoplastic tissue. Many …

Five vascular endothelial growth factor receptor (VEGFR) ligands (VEGF-A,-B,–C,-D, and
placental growth factor [PlGF]) constitute the VEGF family. VEGF-A binds VEGF receptors 1 …

Simple Summary Tumor growth in solid cancers requires adequate nutrient and oxygen
supply, provided by blood vessels created by angiogenesis. Numerous studies have …

Angiogenesis and disruption of liver vascular architecture have been linked to progression
to cirrhosis and liver cancer (HCC) in chronic liver diseases, which contributes both to …

Skin wound healing is a multi stage phenomenon that requires the activation, recruitment or
activity of numerous cell types as keratinocytes, endothelial cells, fibroblast and …