The importance of catalytic promiscuity for enzyme design and evolution

RB Leveson-Gower, C Mayer, G Roelfes - Nature Reviews Chemistry, 2019 - nature.com
The ability of one enzyme to catalyse multiple, mechanistically distinct transformations likely
played a crucial role in organisms' abilities to adapt to changing external stimuli in the past …

Atomic-level design of metalloenzyme-like active pockets in metal–organic frameworks for bioinspired catalysis

W Xu, Y Wu, W Gu, D Du, Y Lin, C Zhu - Chemical Society Reviews, 2024 - pubs.rsc.org
Natural metalloenzymes with astonishing reaction activity and specificity underpin essential
life transformations. Nevertheless, enzymes only operate under mild conditions to keep …

Self‐assembly of multi‐nanozymes to mimic an intracellular antioxidant defense system

Y Huang, Z Liu, C Liu, E Ju, Y Zhang… - Angewandte …, 2016 - Wiley Online Library
In this work, for the first time, we constructed a novel multi‐nanozymes cooperative platform
to mimic intracellular antioxidant enzyme‐based defense system. V2O5 nanowire served as …

[图书][B] Principles of animal nutrition

G Wu - 2017 - taylorfrancis.com
Animals are biological transformers of dietary matter and energy to produce high-quality
foods and wools for human consumption and use. Mammals, birds, fish, and shrimp require …

Enzyme encapsulation in metal–organic frameworks for applications in catalysis

MB Majewski, AJ Howarth, P Li, MR Wasielewski… - …, 2017 - pubs.rsc.org
Enzymes are natural catalysts which are highly selective and efficient. Given that enzymes
have very intricate and delicate structures, they need to be stabilized and protected by a …

[HTML][HTML] Elucidating the role of metal ions in carbonic anhydrase catalysis

JK Kim, C Lee, SW Lim, A Adhikari, JT Andring… - Nature …, 2020 - nature.com
Why metalloenzymes often show dramatic changes in their catalytic activity when subjected
to chemically similar but non-native metal substitutions is a long-standing puzzle. Here, we …

[HTML][HTML] Retinal pigment epithelium 65 kDa protein (RPE65): An update

PD Kiser - Progress in retinal and eye research, 2022 - Elsevier
Vertebrate vision critically depends on an 11-cis-retinoid renewal system known as the
visual cycle. At the heart of this metabolic pathway is an enzyme known as retinal pigment …

Transition metal catalysis in living cells: progress, challenges, and novel supramolecular solutions

CC James, B de Bruin, JNH Reek - Angewandte Chemie …, 2023 - Wiley Online Library
The importance of transition metal catalysis is exemplified by its wide range of applications,
for example in the synthesis of chemicals, natural products, and pharmaceuticals. However …

[HTML][HTML] Bound oxygen-atom transfer endows peroxidase-mimic M–N–C with high substrate selectivity

X Chen, L Zhao, K Wu, H Yang, Q Zhou, Y Xu… - Chemical …, 2021 - pubs.rsc.org
Advances in nanoscience have stimulated the wide exploration of nanozymes as
alternatives to enzymes. Nonetheless, nanozymes often catalyze multiple reactions and are …

ZIF-90 with biomimetic Zn–N coordination structures as an effective nanozyme to mimic natural hydrolase

C Fan, Y Tang, H Wang, Y Huang, F Xu, Y Yang… - Nanoscale, 2022 - pubs.rsc.org
Inspired by the structures of enzymes, a fast and robust strategy for generating ZIF-90
metallo-nanozymes is presented. The Zn–N coordination structure in ZIF-90 can closely …