Neurotrophins are initially synthesized as larger precursors (proneurotrophins), which
undergo proteolytic cleavage to yield mature forms. Although the functions of the mature …

The p75 neurotrophin receptor (p75 NTR) functions at the molecular nexus of cell death,
survival, and differentiation. In addition to its contribution to neurodegenerative diseases and …

The 75 kDa neurotrophin receptor (p75NTR) and two neurotrophin receptor homologs
(NRH1, NRH2) constitute a subfamily of the nerve growth factor/tumor necrosis factor …

The p75 neurotrophin receptor regulates neuronal survival, promoting it in some contexts yet
activating apoptosis in others. The mechanism by which the receptor elicits these differential …

The cytokine tumor necrosis factor was originally identified as a protein that kills tumor cells.
So far, 18 distinct members of this family have been identified. All of them regulate cell …

At vanishingly low concentrations, factors of the neurotrophin family (NGF, BDNF, NT3 and
NT4/5) can promote neuronal survival or death. Many investigations indicate that the …

Bredesen, Dale E., Patrick Mehlen, and Shahrooz Rabizadeh. Apoptosis and Dependence
Receptors: A Molecular Basis for Cellular Addiction. Physiol Rev 84: 411–430, 2004; …

Cells depend for their survival on stimulation by trophic factors and other prosurvival signals,
the withdrawal of which induces apoptosis, both via the loss of antiapoptotic signaling and …

The common neurotrophin receptor p75NTR remains one of the most enigmatic of the tumor
necrosis factor receptor (TNFR) superfamily: on the one hand, it displays a death domain …

One of the most important pathological features of Alzheimer's disease (AD) is extracellular
senile plaques, whose major component is amyloid‐β peptides (Aβ). Aβ binds to the …