The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …

Non-alcoholic fatty liver disease (NAFLD) increases the risk of various liver injuries, ranging
from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and …

The consumption of a quercetin-rich diet has been well-established as a feasible method
against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms …

Background The intestinal epithelial barrier is the interface for interaction between gut
microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key …

Hepatocellular carcinoma (HCC), also known as hepatoma, is a primary malignancy of the
liver and the third leading cause of cancer mortality globally. Although much attention has …

The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H
(CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily …

Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly serious disease
worldwide. Unfortunately, no specific drug has been approved to treat NAFLD. Accumulating …

In the 21st century, intestinal homeostatic imbalance has emerged as a growing health
challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty …

Nonalcoholic fatty liver disease (NAFLD), a spectrum of liver diseases characterized by
excessive fat accumulation, is the leading cause of chronic liver disease. The global …

Non-parenchymal hepatic cell types exhibit some similarity in their responses to lipid
excess, and in their pathogenic mechanisms, which likely contribute to the coordinated …