The liver as an endocrine organ—linking NAFLD and insulin resistance
MJ Watt, PM Miotto, W De Nardo… - Endocrine …, 2019 - academic.oup.com
The liver is a dynamic organ that plays critical roles in many physiological processes,
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
including the regulation of systemic glucose and lipid metabolism. Dysfunctional hepatic …
MicroRNAs in the pathogenesis and treatment of progressive liver injury in NAFLD and liver fibrosis
Non-alcoholic fatty liver disease (NAFLD) increases the risk of various liver injuries, ranging
from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and …
from simple steatosis to non-alcoholic steatohepatitis (NASH), fibrosis and cirrhosis, and …
Quercetin ameliorates HFD-induced NAFLD by promoting hepatic VLDL assembly and lipophagy via the IRE1a/XBP1s pathway
X Zhu, T Xiong, P Liu, X Guo, L Xiao, F Zhou… - Food and chemical …, 2018 - Elsevier
The consumption of a quercetin-rich diet has been well-established as a feasible method
against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms …
against non-alcoholic fatty liver disease (NAFLD); however, the molecular mechanisms …
[HTML][HTML] Akkermansia muciniphila and its membrane protein ameliorates intestinal inflammatory stress and promotes epithelial wound healing via CREBH and miR …
H Wade, K Pan, Q Duan, S Kaluzny, E Pandey… - Journal of Biomedical …, 2023 - Springer
Background The intestinal epithelial barrier is the interface for interaction between gut
microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key …
microbiota and host metabolic systems. Akkermansia muciniphila (A. muciniphila) is a key …
[HTML][HTML] Endoplasmic reticulum stress signaling and the pathogenesis of hepatocarcinoma
Hepatocellular carcinoma (HCC), also known as hepatoma, is a primary malignancy of the
liver and the third leading cause of cancer mortality globally. Although much attention has …
liver and the third leading cause of cancer mortality globally. Although much attention has …
[HTML][HTML] CREBH regulates systemic glucose and lipid metabolism
Y Nakagawa, H Shimano - International journal of molecular sciences, 2018 - mdpi.com
The cyclic adenosine monophosphate (cAMP)-responsive element-binding protein H
(CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily …
(CREBH, encoded by CREB3L3) is a membrane-bound transcriptional factor that primarily …
[HTML][HTML] Targeting lipophagy as a potential therapeutic strategy for nonalcoholic fatty liver disease
HY Li, ZG Peng - Biochemical Pharmacology, 2022 - Elsevier
Nonalcoholic fatty liver disease (NAFLD) is becoming an increasingly serious disease
worldwide. Unfortunately, no specific drug has been approved to treat NAFLD. Accumulating …
worldwide. Unfortunately, no specific drug has been approved to treat NAFLD. Accumulating …
[HTML][HTML] Palmitic acid induces intestinal lipid metabolism disorder, endoplasmic reticulum stress and inflammation by affecting phosphatidylethanolamine content in …
W Fang, Y Liu, Q Chen, D Xu, Q Liu, X Cao… - Frontiers in …, 2022 - frontiersin.org
In the 21st century, intestinal homeostatic imbalance has emerged as a growing health
challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty …
challenge worldwide. Accumulating evidence reveals that excessive intake of saturated fatty …
[HTML][HTML] Nonalcoholic fatty liver disease and insulin resistance in children
K Song, HS Kim, HW Chae - Clinical and Experimental Pediatrics, 2023 - ncbi.nlm.nih.gov
Nonalcoholic fatty liver disease (NAFLD), a spectrum of liver diseases characterized by
excessive fat accumulation, is the leading cause of chronic liver disease. The global …
excessive fat accumulation, is the leading cause of chronic liver disease. The global …
[HTML][HTML] Non-parenchymal hepatic cell lipotoxicity and the coordinated progression of non-alcoholic fatty liver disease and atherosclerosis
KM Peters, RB Wilson… - Current opinion in …, 2018 - journals.lww.com
Non-parenchymal hepatic cell types exhibit some similarity in their responses to lipid
excess, and in their pathogenic mechanisms, which likely contribute to the coordinated …
excess, and in their pathogenic mechanisms, which likely contribute to the coordinated …