Anthrax is a severe, although rather rare, infectious disease that is caused by the Gram-
positive, spore-forming bacterium Bacillus anthracis. The infectious form is the spore and the …

Proteins are essential for life, as they participate in all vital processes in the body. In the past
decade, delivery of active proteins to specific cells and organs has attracted increasing …

Transplantation of neural stem cells (NSCs) is a promising treatment paradigm to replace
lost neurons and reconstruct the damaged neural circuit after ischemic stroke. However …

Bacterial products can act on neurons to alter signaling and function. In the present study,
we found that dorsal root ganglion (DRG) sensory neurons are enriched for ANTXR2, the …

The natural world has provided a host of materials and inspiration for the field of
nanomedicine. By taking design cues from naturally occurring systems, the …

The intracellular delivery of peptide and protein therapeutics is a major challenge due to the
plasma membrane, which acts as a barrier between the extracellular environment and the …

Targeted delivery of therapeutic proteins toward specific cells and across cell membranes
remains major challenges. Here, we develop protein-based delivery systems utilizing …

As the fourth commonest malignancy among females worldwide, cervical cancer (CC) poses
a huge challenge to human health. The pivotal regulatory roles of lncRNAs in cancers have …

Glioblastoma (GBM) is the most malignant form of all primary brain tumors, and it is
responsible for around 200,000 deaths each year worldwide. The standard therapy for GBM …

Despite enormous efforts, achieving efficacious levels of proteins inside mammalian cells
remains one of the greatest challenges in biologics-based drug discovery and development …